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Review
. 2016 Jun;15(3):400-6.
doi: 10.1111/acel.12455. Epub 2016 Feb 22.

Cellular senescence impact on immune cell fate and function

Rita Vicente  1   2   3 , Anne-Laure Mausset-Bonnefont  1   2   3 , Christian Jorgensen  1   2   3 , Pascale Louis-Plence  1   2   3 , Jean-Marc Brondello  1   2   3
Affiliations
Review

Cellular senescence impact on immune cell fate and function

Rita Vicente et al. Aging Cell. 2016 Jun.

Abstract

Cellular senescence occurs not only in cultured fibroblasts, but also in undifferentiated and specialized cells from various tissues of all ages, in vitro and in vivo. Here, we review recent findings on the role of cellular senescence in immune cell fate decisions in macrophage polarization, natural killer cell phenotype, and following T-lymphocyte activation. We also introduce the involvement of the onset of cellular senescence in some immune responses including T-helper lymphocyte-dependent tissue homeostatic functions and T-regulatory cell-dependent suppressive mechanisms. Altogether, these data propose that cellular senescence plays a wide-reaching role as a homeostatic orchestrator.

Keywords: cellular senescence; chronic and autoimmune diseases; immune cells; tissue homeostasis.

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