Stem cells versus plasticity in liver and pancreas regeneration

doi:10.1038/ncb3309

Review

. 2016 Mar;18(3):238-45.

doi: 10.1038/ncb3309.

Stem cells versus plasticity in liver and pancreas regeneration

Janel L Kopp¹, Markus Grompe², Maike Sander³

Affiliations

¹ Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
² Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University, Portland, Oregon 97239, USA.
³ Department of Pediatrics and Cellular and Molecular Medicine, Pediatric Diabetes Research Center, Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, California 92093-0695, USA.

PMID: 26911907
DOI: 10.1038/ncb3309

Review

Stem cells versus plasticity in liver and pancreas regeneration

Janel L Kopp et al. Nat Cell Biol. 2016 Mar.

. 2016 Mar;18(3):238-45.

doi: 10.1038/ncb3309.

Authors

Janel L Kopp¹, Markus Grompe², Maike Sander³

Affiliations

¹ Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
² Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University, Portland, Oregon 97239, USA.
³ Department of Pediatrics and Cellular and Molecular Medicine, Pediatric Diabetes Research Center, Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, California 92093-0695, USA.

PMID: 26911907
DOI: 10.1038/ncb3309

Abstract

Cell replacement in adult organs can be achieved through stem cell differentiation or the replication or transdifferentiation of existing cells. In the adult liver and pancreas, stem cells have been proposed to replace tissue cells, particularly following injury. Here we review how specialized cell types are produced in the adult liver and pancreas. Based on current evidence, we propose that the plasticity of differentiated cells, rather than stem cells, accounts for tissue repair in both organs.

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References

1. Cancer Cell. 2012 Dec 11;22(6):737-50 - PubMed
1. J Clin Invest. 2007 Sep;117(9):2553-61 - PubMed
1. Nat Med. 2012 Mar 11;18(4):618-23 - PubMed
1. Diabetes. 2013 May;62(5):1634-45 - PubMed
1. Liver. 1985 Dec;5(6):293-300 - PubMed

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[1] Cancer Cell. 2012 Dec 11;22(6):737-50 - PubMed

[2] Cancer Cell. 2012 Dec 11;22(6):737-50 - PubMed

[3] J Clin Invest. 2007 Sep;117(9):2553-61 - PubMed

[4] J Clin Invest. 2007 Sep;117(9):2553-61 - PubMed

[5] Nat Med. 2012 Mar 11;18(4):618-23 - PubMed

[6] Nat Med. 2012 Mar 11;18(4):618-23 - PubMed

[7] Diabetes. 2013 May;62(5):1634-45 - PubMed

[8] Diabetes. 2013 May;62(5):1634-45 - PubMed

[9] Liver. 1985 Dec;5(6):293-300 - PubMed

[10] Liver. 1985 Dec;5(6):293-300 - PubMed

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Stem cells versus plasticity in liver and pancreas regeneration

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Stem cells versus plasticity in liver and pancreas regeneration

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