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Review
. 2016 Mar;18(3):238-45.
doi: 10.1038/ncb3309.

Stem cells versus plasticity in liver and pancreas regeneration

Janel L Kopp  1 , Markus Grompe  2 , Maike Sander  3
Affiliations
Review

Stem cells versus plasticity in liver and pancreas regeneration

Janel L Kopp et al. Nat Cell Biol. 2016 Mar.

Abstract

Cell replacement in adult organs can be achieved through stem cell differentiation or the replication or transdifferentiation of existing cells. In the adult liver and pancreas, stem cells have been proposed to replace tissue cells, particularly following injury. Here we review how specialized cell types are produced in the adult liver and pancreas. Based on current evidence, we propose that the plasticity of differentiated cells, rather than stem cells, accounts for tissue repair in both organs.

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References

    1. Cancer Cell. 2012 Dec 11;22(6):737-50 - PubMed
    1. J Clin Invest. 2007 Sep;117(9):2553-61 - PubMed
    1. Nat Med. 2012 Mar 11;18(4):618-23 - PubMed
    1. Diabetes. 2013 May;62(5):1634-45 - PubMed
    1. Liver. 1985 Dec;5(6):293-300 - PubMed

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