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Review
. 2016 Mar;18(3):246-54.
doi: 10.1038/ncb3312.

Organoids as an in vitro model of human development and disease

Affiliations
Review

Organoids as an in vitro model of human development and disease

Aliya Fatehullah et al. Nat Cell Biol. 2016 Mar.

Abstract

The in vitro organoid model is a major technological breakthrough that has already been established as an essential tool in many basic biology and clinical applications. This near-physiological 3D model facilitates an accurate study of a range of in vivo biological processes including tissue renewal, stem cell/niche functions and tissue responses to drugs, mutation or damage. In this Review, we discuss the current achievements, challenges and potential applications of this technique.

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References

    1. Nature. 2014 Dec 18;516(7531):400-4 - PubMed
    1. Nat Med. 2012 Mar 11;18(4):618-23 - PubMed
    1. EMBO Rep. 2011 Jun;12(6):558-64 - PubMed
    1. Nat Cell Biol. 2014 Jan;16(1):118-26 - PubMed
    1. Mol Carcinog. 2015 Mar;54(3):189-202 - PubMed

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