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Review
. 2016 Feb 25:6:22089.
doi: 10.1038/srep22089.

Prognostic significance of neutrophil-to-lymphocyte ratio in prostate cancer: evidence from 16,266 patients

Xiaobin Gu  1 , Xianshu Gao  1 , Xiaoying Li  1 , Xin Qi  1 , Mingwei Ma  1 , Shangbin Qin  1 , Hao Yu  1 , Shaoqian Sun  1 , Dong Zhou  1 , Wen Wang  1
Affiliations
Review

Prognostic significance of neutrophil-to-lymphocyte ratio in prostate cancer: evidence from 16,266 patients

Xiaobin Gu et al. Sci Rep. .

Abstract

This study was aimed to investigate the prognostic value of neutrophil-to-lymphocyte ratio (NLR) in patients with prostate cancer (PCa). A meta-analysis including 14 publications (15 cohorts) with 16,266 patients was performed to evaluate the association between NLR and overall survival (OS), progression-free survival (PFS)/recurrence-free survival (RFS) in PCa using hazard ratio (HR) and 95% confidence intervals (95% CI). The combining data showed that increased NLR predict poor OS (HR = 1.38, 95%CI: 1.22-1.56) and PFS/RFS (HR = 1.24, 95%CI 1.05-1.46) in PCa. Stratified analysis by PCa type, sample size, ethnicity and NLR cut-off value revealed that NLR showed consistent prognostic value in metastatic castration-resistant prostate cancer (mCRPC) patients and predict poor PFS/RFS in Asians, but not in Caucasians. These statistical data suggested that increased NLR could predict poor prognosis in patients with PCa.

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Figures

Figure 1
Figure 1. The flow chart of literature selection.
Figure 2
Figure 2. Meta-analysis of the association between elevated NLR and OS.
Figure 3
Figure 3. Meta-analysis of the association between elevated NLR and PFS/RFS.
Figure 4
Figure 4
Sensitivity analysis on the relationship between NLR and (A) OS and (B) PFS/RFS in PCa.
Figure 5
Figure 5
Begg’s funnel plot of publication bias test for (A) OS and (B) PFS/RFS in PCa.
See this image and copyright information in PMC

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