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Comment
. 2016 Feb 12;351(6274):661-2.
doi: 10.1126/science.aaf1647.

MOLECULAR BIOLOGY. A unifying model of epigenetic regulation

Albert J Keung  1 , Ahmad S Khalil  2
Affiliations
Comment

MOLECULAR BIOLOGY. A unifying model of epigenetic regulation

Albert J Keung et al. Science. .
No abstract available

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Figures

Figure 1
Figure 1. Unifying epigenetic regulation
(A) A proposed three-state model of gene regulation by repressive CRs, in which cells stochastically transition between active, reversibly silent, and irreversibly silent states. (B) The model is obtained by quantifying silencing events in individual cells during CR recruitment, and reactivation events upon release of the CR, by means of time-lapse microscopy. Filmstrips for two CRs are shown. DNMT3B induces slow but complete commitment to irreversibly silent states, whereas HDAC4 leads to rapid silencing and reactivation. (C) Duration-dependent fractional control of long-term (irreversible) silencing.
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References

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