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Review
. 2016 Jun;63(6):973-82.
doi: 10.1002/pbc.25939. Epub 2016 Feb 23.

Minimal Residual Disease and Childhood Leukemia: Standard of Care Recommendations From the Pediatric Oncology Group of Ontario MRD Working Group

Uma H Athale  1   2 , Paul J Gibson  3   4 , Nicole M Bradley  5 , David M Malkin  5   6   7   8 , Johann Hitzler  6   7 ; POGO MRD Working Group
Affiliations
Review

Minimal Residual Disease and Childhood Leukemia: Standard of Care Recommendations From the Pediatric Oncology Group of Ontario MRD Working Group

Uma H Athale et al. Pediatr Blood Cancer. 2016 Jun.

Abstract

Minimal residual disease (MRD) is an independent predictor of relapse risk in children with leukemia and is widely used for risk-adapted treatment. This article summarizes current evidence supporting the use of MRD, including clinical significance, current international clinical practice, impact statement, and recommended indications. The proposed MRD recommendations have been endorsed by the MRD Working Group of the Pediatric Oncology Group of Ontario and provide the foundation for a strategy that aims at equitable access to MRD evaluation for children with leukemia.

Keywords: acute lymphoblastic leukemia; acute myeloid leukemia; hematopoietic stem cell transplantation; leukemia; leukemic relapse; minimal residual disease; pediatric; prognostication; risk stratification.

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