Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Feb 25;12(2):e1005390.
doi: 10.1371/journal.ppat.1005390. eCollection 2016 Feb.

Emerging Paramyxoviruses: Receptor Tropism and Zoonotic Potential

Antra Zeltina  1 , Thomas A Bowden  1 , Benhur Lee  2
Affiliations

Emerging Paramyxoviruses: Receptor Tropism and Zoonotic Potential

Antra Zeltina et al. PLoS Pathog. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1
Maximum likelihood phylogenies of Paramyxoviridae L (A), F (B), and HN/H/G (C) protein sequences using MEGA6 (Molecular Evolutionary Genetics Analysis Version 6.0) [34], based on the LG+G+I+F model [35]. Scale bar indicates amino acid substitutions per site. Numbers at the nodes represent bootstrap values (1,000 replicates). Colored circles are used to indicate genera and empty black circles indicate viruses with varying positions between the L, F, and HN/H/G phylogenies. Uncategorized viruses awaiting taxonomic evaluation by the International Committee on Taxonomy of Viruses are marked with an asterisk. Virus names (abbreviations) and GenBank accession numbers are as follows: Mojiang virus (MojPV) NC_025352; Ghanaian bat henipavirus (GhV) HQ660129; Cedar virus (CedPV) NC_025351; Nipah virus (NiV) NC_002728; Hendra virus (HeV) NC_001906; Sendai virus (SeV) NC_001552; human parainfluenza virus 1 (hPIV1) NC_003461; human parainfluenza virus 3 (hPIV3) AY283063 (for HN) and NC_001796.2 (for L and F); bovine parainfluenza virus 3 (bPIV3) NC_002161; Tuhoko virus 1 (ThkPV1) NC_025410; Menangle virus (MenPV) NC_007620; Tioman virus (TioPV) NC_004074; parainfluenza virus 5 (PIV5) NC_006430; human parainfluenza virus 2 (hPIV2) NC_003443; porcine rubulavirus (PorPV) NC_009640; mumps virus (MuV) NC_002200; avian paramyxovirus 6 (APMV6) NC_003043; Newcastle disease virus (NDV) AF212323 (for HN) and NC_002617 (for L and F); canine distemper virus (CDV) AY386315; peste-des-petits-ruminants virus (PPRV) FJ905304; rinderpest virus (RPV) JN234010; measles virus (MeV) NC_001498; Mossman virus (MosPV) NC_005339; Nariva virus (NarPV) NC_017937.1; Beilong virus (BeiPV) NC_007803; Tailam virus (TaiPV) NC_025355; J paramyxovirus (JPV) NC_007454; Salem virus (SalPV) NC_025386; Fer-de-lance virus (FdlPV) NC_005084; Atlantic salmon paramyxovirus (AsaPV) NC_025360; Tupaia paramyxovirus (TupPV) NC_002199; feline morbillivirus (FmoPV) JQ411014.
Fig 2
Fig 2. Mapping sequence conservation onto henipavirus and morbillivirus attachment glycoproteins.
(A) Crystal structure of Ghanaian bat henipavirus attachment glycoprotein (GhV-G, PDB [Protein Data Bank] ID 4UF7) in complex with ephrinB2. EphrinB2 is shown as a yellow ribbon and GhV-G is shown in surface representation and colored according to sequence conservation with (left to right) HeV-G, NiV-G, CedPV-G, and MojPV-G. Sequence identical residues are colored red and similar residues pink. At the bottom of the panel are tables summarizing overall glycoprotein sequence identity (bottom right) and sequence similarity at the ephrin receptor-binding site (top left), with respect to GhV-G. (B) Crystal structure of measles virus hemagglutinin (MeV-H) in complex with nectin-4 cell surface receptor (PDB ID 4GJT), with the position of SLAM/F1 (green ribbon) receptor-binding shown (based upon structural overlay with the MeV-H-SLAM/F1 crystal structure; PDB ID 3ALZ). Nectin-4 and SLAM/F1 are shown as cyan and green ribbons, respectively. MeV-H is shown in surface representation and colored according to sequence conservation, as in panel A, with RPV-H, PPRV-H, CDV-H, FmoPV-H, and SalPV-G (left to right). At the bottom of the panel are tables summarizing overall glycoprotein sequence identity (bottom right) and sequence similarity at the nectin-4– (top) and SLAM/F1-binding sites (left), with respect to MeV-H. The tables are color-coded from dark gray (highly conserved) to white (variable).
See this image and copyright information in PMC

References

    1. Jones KE, Patel NG, Levy MA, Storeygard A, Balk D, Gittleman JL, et al. Global trends in emerging infectious diseases. Nature. 2008;451(7181):990–3. 10.1038/nature06536 . - DOI - PMC - PubMed
    1. Drexler JF, Corman VM, Muller MA, Maganga GD, Vallo P, Binger T, et al. Bats host major mammalian paramyxoviruses. Nat Commun. 2012;3:796 10.1038/ncomms1796 - DOI - PMC - PubMed
    1. Woo PC, Lau SK, Wong BH, Wong AY, Poon RW, Yuen KY. Complete genome sequence of a novel paramyxovirus, Tailam virus, discovered in Sikkim rats. J Virol. 2011;85(24):13473–4. 10.1128/JVI.06356-11 - DOI - PMC - PubMed
    1. Miller PJ, Boyle DB, Eaton BT, Wang LF. Full-length genome sequence of Mossman virus, a novel paramyxovirus isolated from rodents in Australia. Virology. 2003;317(2):330–44. . - PubMed
    1. Brooks F, Wood AR, Thomson J, Deane D, Everest DJ, McInnes CJ. Preliminary characterisation of Pentlands paramyxovirus-1, -2 and -3, three new paramyxoviruses of rodents. Vet Microbiol. 2014;170(3–4):391–7. 10.1016/j.vetmic.2014.02.010 . - DOI - PubMed

Publication types

MeSH terms