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Randomized Controlled Trial
. 2016 Mar;7(2):71-80.
doi: 10.1016/j.jgo.2016.02.002. Epub 2016 Feb 23.

Novel physical activity interventions for older patients with prostate cancer on hormone therapy: A pilot randomized study

Saleha Sajid  1 , William Dale  2 , Karen Mustian  3 , Ashwin Kotwal  4 , Charles Heckler  5 , Michelle Porto  5 , Chunkit Fung  6 , Supriya G Mohile  7
Affiliations
Randomized Controlled Trial

Novel physical activity interventions for older patients with prostate cancer on hormone therapy: A pilot randomized study

Saleha Sajid et al. J Geriatr Oncol. 2016 Mar.

Abstract

Background: Androgen deprivation therapy (ADT) can decrease the physical performance (PP) of older men with prostate cancer (PC).

Methods: We conducted a three-arm randomized pilot study (n=19) comparing a home-based walking and resistance intervention (EXCAP) and a technology-mediated walking and resistance intervention using Wii-Fit to a usual-care arm in men ≥70 years with PC receiving ADT. The intervention lasted for 6 weeks, with follow-up at 12 weeks. The primary pre-specified outcome was change in Short Physical Performance Battery (SPPB) score. Mixed effects regression models were used to assess change in outcomes over time.

Results: Mean participant age was 70 years (range: 67-93). Eight patients were randomized to the Wii-Fit arm, 6 to the EXCAP arm, and 5 to the usual-care arm. SPPB scores remained nearly constant in the usual-care arm (β=-0.12; p=0.79), while individuals in the EXCAP arm had on average a 1.2 point increase at each follow-up (β=1.20; 95% CI: 0.36, 2.06). The Wii-fit arm had a non-significant increase in SPPB score over time relative to usual-care (β=0.32; 95% CI -0.43, 1.06; p=0.46). Individuals in the EXCAP arm had an increase in steps per day over time compared to the usual-care arm (p-value=0.006); the EXCAP arm had an increase of 2720 steps (95% CI: 1313, 4128) while the usual-care arm had an increase of 97 steps (95% CI: -1140, 1333). Participants in the Wii-Fit arm had an increase of 1020 steps (95% CI: -474, 1238, p=0.710). Other outcomes (i.e., handgrip strength, lean muscle mass, and chest press repetitions) were not statistically significant.

Conclusions: A home-based aerobic and resistance exercise program, EXCAP, shows promise for improving PP in older men with PC on ADT.

Keywords: Androgen deprivation therapy; Elderly; Home-based exercise interventions; Older adults; Prostate cancer; Wii-Fit.

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Figure 1
Figure 1
Study Schema
Figure 2
Figure 2
Change in SPPB Score for each participant by study group
Figure 3
Figure 3
Adjusted estimates of the change in outcomes over time by study groups
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References

    1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA: a cancer journal for clinicians. 2013;63(1):11–30. - PubMed
    1. Moul JW. Prostate specific antigen only progression of prostate cancer. The Journal of urology. 2000;163(6):1632–42. - PubMed
    1. Shahinian VB, Kuo YF, Freeman JL, Orihuela E, Goodwin JS. Increasing use of gonadotropin-releasing hormone agonists for the treatment of localized prostate carcinoma. Cancer. 2005;103(8):1615–24. - PubMed
    1. Cooperberg MR, Grossfeld GD, Lubeck DP, Carroll PR. National practice patterns and time trends in androgen ablation for localized prostate cancer. Journal of the National Cancer Institute. 2003;95(13):981–9. - PMC - PubMed
    1. Salminen EK, Wickstrom JE, Vahlberg T, Duchesne GM. Trends in the use of androgen deprivation in prostate cancer. Acta oncologica. 2004;43(4):382–7. - PubMed

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