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Observational Study
. 2016 Feb 25;6(2):e010542.
doi: 10.1136/bmjopen-2015-010542.

Cohort for Tuberculosis Research by the Indo-US Medical Partnership (CTRIUMPH): protocol for a multicentric prospective observational study

Akshay Gupte  1 , Chandrasekaran Padmapriyadarsini  2 , Vidya Mave  3 , Dileep Kadam  4 , Nishi Suryavanshi  5 , Shri Vijay Bala Yogendra Shivakumar  2 , Rewa Kohli  5 , Nikhil Gupte  3 , Kannan Thiruvengadam  2 , Anju Kagal  4 , Sushant Meshram  4 , Renu Bharadwaj  4 , Sandhya Khadse  4 , Geetha Ramachandran  2 , Luke Elizabeth Hanna  2 , Neeta Pradhan  5 , N S Gomathy  2 , Andrea DeLuca  1 , Amita Gupta  1 , Soumya Swaminathan  6 ; CTRIUMPH Study Team
Collaborators, Affiliations
Observational Study

Cohort for Tuberculosis Research by the Indo-US Medical Partnership (CTRIUMPH): protocol for a multicentric prospective observational study

Akshay Gupte et al. BMJ Open. .

Abstract

Introduction: Tuberculosis disease (TB) remains an important global health threat. An evidence-based response, tailored to local disease epidemiology in high-burden countries, is key to controlling the global TB epidemic. Reliable surrogate biomarkers that predict key active disease and latent TB infection outcomes are vital to advancing clinical research necessary to 'End TB'. Well executed longitudinal studies strengthening local research capacity for addressing TB research priorities and advancing biomarker discovery are urgently needed.

Methods and analysis: The Cohort for Tuberculosis Research by the Indo-US Medical Partnership (CTRIUMPH) study conducted in Byramjee Jeejeebhoy Government Medical College (BJGMC), Pune and National Institute for Research in Tuberculosis (NIRT), Chennai, India, will establish and maintain three prospective cohorts: (1) an Active TB Cohort comprising 800 adults with pulmonary TB, 200 adults with extrapulmonary TB and 200 children with TB; (2) a Household Contact Cohort of 3200 adults and children at risk of developing active disease; and (3) a Control Cohort consisting of 300 adults and 200 children with no known exposure to TB. Relevant clinical, sociodemographic and psychosocial data will be collected and a strategic specimen repository established at multiple time points over 24 months of follow-up to measure host and microbial factors associated with (1) TB treatment outcomes; (2) progression from infection to active TB disease; and (3) Mycobacterium tuberculosis transmission among Indian adults and children. We anticipate CTRIUMPH to serve as a research platform necessary to characterise some relevant aspects of the TB epidemic in India, generate evidence to inform local and global TB control strategies and support novel TB biomarker discovery.

Ethics and dissemination: This study is approved by the Institutional Review Boards of NIRT, BJGMC and Johns Hopkins University, USA. Study results will be disseminated through peer-reviewed journals and research conferences.

Funding: NIH/DBT Indo-US Vaccine Action Programme and the Indian Council of Medical Research.

Keywords: EPIDEMIOLOGY.

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References

    1. WHO. Global tuberculosis report Geneva, Switzerland: World Health Organization, 2014.
    1. TB India 2014 Revised National TB Control Program Annual Status Report. New Delhi Central TB Division, Directorate General of Health Services, Ministry of Health and Family Welfare, Government of India, 2014.
    1. Albanna AS, Reed MB, Kotar KV et al. . Reduced transmissibility of East African Indian strains of Mycobacterium tuberculosis. PLoS ONE 2011;6:e25075 10.1371/journal.pone.0025075 - DOI - PMC - PubMed
    1. de Jong BC, Hill PC, Aiken A et al. . Progression to active tuberculosis, but not transmission, varies by Mycobacterium tuberculosis lineage in The Gambia. J Infect Dis 2008;198:1037–43. 10.1086/591504 - DOI - PMC - PubMed
    1. Parwati I, van Crevel R, van Soolingen D. Possible underlying mechanisms for successful emergence of the Mycobacterium tuberculosis Beijing genotype strains. Lancet Infect Dis 2010;10:103–11. 10.1016/S1473-3099(09)70330-5 - DOI - PubMed

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