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Review
. 2016 Apr;83(4):322-7.
doi: 10.1007/s12098-016-2060-z. Epub 2016 Feb 26.

Systemic Juvenile Idiopathic Arthritis: Diagnosis and Management

Sathish Kumar  1
Affiliations
Review

Systemic Juvenile Idiopathic Arthritis: Diagnosis and Management

Sathish Kumar. Indian J Pediatr. 2016 Apr.

Abstract

Systemic juvenile idiopathic arthritis (sJIA) is an inflammatory condition characterized by fever, lymphadenopathy, arthritis, rash and serositis. In sJIA, systemic inflammation has been associated with dysregulation of the innate immune system, suggesting that it is an autoinflammatory disorder. IL-1 and IL-6 play a major role in the pathogenesis of sJIA and treatment with IL-1 and IL-6 inhibitors has shown to be highly effective. Recent data suggests that early cytokine blockage might abrogate chronic, destructive, therapy resistant arthritis phase, reflecting a potential "window of opportunity" in the care of children with sJIA.

Keywords: Interleukin-1 blockade; Systemic JIA; Treatment.

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