Targeting endoplasmic reticulum acetylation to restore proteostasis in Alzheimer's disease

Affiliations

¹ Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile FONDAP Centre for Geroscience, Brain Health and Metabolism, Santiago, Chile Program of Cellular and Molecular Biology, Centre for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile chetz@med.uchile.cl chetz@hsph.harvard.edu.
² Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile FONDAP Centre for Geroscience, Brain Health and Metabolism, Santiago, Chile Program of Cellular and Molecular Biology, Centre for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston MA, USA.

Comment

Claudia Duran-Aniotz et al. Brain. 2016 Mar.

. 2016 Mar;139(Pt 3):650-2.

doi: 10.1093/brain/awv401.

¹ Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile FONDAP Centre for Geroscience, Brain Health and Metabolism, Santiago, Chile Program of Cellular and Molecular Biology, Centre for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile chetz@med.uchile.cl chetz@hsph.harvard.edu.
² Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile FONDAP Centre for Geroscience, Brain Health and Metabolism, Santiago, Chile Program of Cellular and Molecular Biology, Centre for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston MA, USA.

No abstract available

Comment on

Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse.
Peng Y, Kim MJ, Hullinger R, O'Riordan KJ, Burger C, Pehar M, Puglielli L. Peng Y, et al. Brain. 2016 Mar;139(Pt 3):937-52. doi: 10.1093/brain/awv385. Epub 2016 Jan 19. Brain. 2016. PMID: 26787453 Free PMC article.