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Review
. 2016 Feb 16;8(Suppl 1):41-7.
doi: 10.4137/NMI.S29527. eCollection 2015.

Nutrition During Pregnancy Impacts Offspring's Epigenetic Status-Evidence from Human and Animal Studies

Aisling A Geraghty  1 , Karen L Lindsay  1 , Goiuri Alberdi  1 , Fionnuala M McAuliffe  1 , Eileen R Gibney  2
Affiliations
Review

Nutrition During Pregnancy Impacts Offspring's Epigenetic Status-Evidence from Human and Animal Studies

Aisling A Geraghty et al. Nutr Metab Insights. .

Abstract

Pregnancy is a vital time of growth and development during which maternal nutrition significantly influences the future health of both mother and baby. During pregnancy, the fetus experiences a critical period of plasticity. Epigenetics, specifically DNA methylation, plays an important role here. As nutrition is influential for DNA methylation, this review aims to determine if maternal nutrition during pregnancy can modify the offspring's epigenome at birth. Research focuses on micronutrients and methyl donors such as folate and B vitamins. Evidence suggests that maternal nutrition does not largely influence global methylation patterns, particularly in nutrient-replete populations; however, an important impact on gene-specific methylation is observed. A link is shown between maternal nutrition and the methylome of the offspring; however, there remains a paucity of research. With the potential to use DNA methylation patterns at birth to predict health of the child in later life, it is vital that further research be carried out.

Keywords: epigenetics; nutrition; offspring; pregnancy; programing.

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References

    1. Waterland R, Kellermayer R, Laritsky E, et al. Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles. PLoS Genet. 2010;6(12):1–10. - PMC - PubMed
    1. Grieger J, Clifton V. A review of the impact of dietary intakes in human pregnancy on infant birthweight. Nutrients. 2014;7(1):153–178. - PMC - PubMed
    1. Walsh J, McAuliffe F. Impact of maternal nutrition on pregnancy outcome—does it matter what pregnant women eat? Best Pract Res Clin Obstet Gynaecol. 2015;29(1):63–78. - PubMed
    1. Gresham E, Byles J, Bisquera A, Hure A. Effects of dietary interventions on neonatal and infant outcomes: a systematic review and meta-analysis. Am J Clin Nutr. 2014;100(5):1298–1321. - PubMed
    1. Dubois L, Ohm Kyvik K, Girard M, et al. Genetic and environmental contributions to weight, height, and BMI from birth to 19 years of age: an international study of over 12,000 twin pairs. PLoS One. 2012;7(2):e30153. - PMC - PubMed

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