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Review
. 2016 Feb 11:5:F1000 Faculty Rev-161.
doi: 10.12688/f1000research.7352.1. eCollection 2016.

Recent advances in the understanding and management of IgA nephropathy

Kar Neng Lai  1 , Joseph C K Leung  2 , Sydney C W Tang  2
Affiliations
Review

Recent advances in the understanding and management of IgA nephropathy

Kar Neng Lai et al. F1000Res. .

Abstract

Since its first description in 1968, IgA nephropathy has remained the most common form of primary glomerulonephritis leading to chronic kidney disease in developed countries. The clinical progression varies, and consequent end-stage renal disease occurs in 30% to 40% of patients 20 to 30 years after the first clinical presentation. Current data implicate overproduction of aberrantly glycosylated IgA1 as being pivotal in the induction of renal injury. Effective and specific treatment is still lacking, and new therapeutic approaches will be developed after better understanding the disease pathogenesis.

Keywords: Familial IgAN; IgA nephropathy; end-stage renal disease; genetics of IgAN; glomerulonephritis; treatment IgAn.

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Conflict of interest statement

Competing interests: The authors declare that they have no competing interests.

No competing interests were disclosed.

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