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Review
. 2016 Jan 26:5:F1000 Faculty Rev-105.
doi: 10.12688/f1000research.7404.1. eCollection 2016.

West Nile Virus Infection in the Central Nervous System

Evandro R Winkelmann  1 , Huanle Luo  1 , Tian Wang  2
Affiliations
Review

West Nile Virus Infection in the Central Nervous System

Evandro R Winkelmann et al. F1000Res. .

Abstract

West Nile virus (WNV), a neurotropic single-stranded flavivirus has been the leading cause of arboviral encephalitis worldwide. Up to 50% of WNV convalescent patients in the United States were reported to have long-term neurological sequelae. Neither antiviral drugs nor vaccines are available for humans. Animal models have been used to investigate WNV pathogenesis and host immune response in humans. In this review, we will discuss recent findings from studies in animal models of WNV infection, and provide new insights on WNV pathogenesis and WNV-induced host immunity in the central nervous system.

Keywords: West Nile Virus; arboviral encephalitis; central nervous system infection; flavivirus; west nile virus infection in central nervous system.

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Conflict of interest statement

Competing interests: The authors declare that they have no competing interests.

No competing interests were disclosed.

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