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Case Reports
. 2016 Feb;6(1):e4-e7.
doi: 10.1212/CPJ.0000000000000199.

Electrographic status epilepticus in sleep in an adult with cerebral folate deficiency

Ursula Thome  1 , Paula Klima  1 , Ahsan N V Moosa  1 , Ajay Gupta  1 , Sumit Parikh  1 , Elia M Pestana Knight  1
Affiliations
Case Reports

Electrographic status epilepticus in sleep in an adult with cerebral folate deficiency

Ursula Thome et al. Neurol Clin Pract. 2016 Feb.
No abstract available

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Figures

Figure 1
Figure 1. Exponential growth curve
Exponential growth curve was fit to data between 2009 and initiation of folinic acid, yielding a growth rate in seizure frequency. Patient age 20.8–27.9 years. Colored lines show the initial treatment with diazepam and folinic acid. There was a transitory improvement in seizure frequency after treatment with diazepam. (A) Monthly seizure frequency showing a sharp drop after start of folinic acid treatment (November 7, 2014, month circled). (B) Weekly seizure frequency, weeks numbered from the start of folinic acid treatment; note the frequency decrease apparent 8–10 weeks after beginning folinic acid.
Figure 2
Figure 2. Imaging
(A, B) EEG recording during admission. (A) Patient awake with normal posterior background and focal epileptiform discharge in the right frontocentral region. (B) Patient asleep with continuous spike-and-wave discharges covering the whole tracing and occupying >85% of slow-wave sleep, consistent with electrographic status epilepticus in sleep. (C) EEG recording after treatment with diazepam. (D) Brain MRI.
See this image and copyright information in PMC

References

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