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Comment
. 2016 Feb 25;164(5):840-2.
doi: 10.1016/j.cell.2016.02.024.

EMT: Matter of Life or Death?

Sonal Gupta  1 , Anirban Maitra  2
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Free article
Comment

EMT: Matter of Life or Death?

Sonal Gupta et al. Cell. .
Free article

Abstract

TGF-β is long considered a "protean" cytokine in cancer, changing its role from anti- to pro-tumorigenic in a context-dependent manner. In this issue of Cell, David et al. use mouse models of pancreatic cancer to shed light on the mechanistic basis of how TGF-β-induced EMT is coupled to either apoptosis or tumor progression.

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  • TGF-β Tumor Suppression through a Lethal EMT.
    David CJ, Huang YH, Chen M, Su J, Zou Y, Bardeesy N, Iacobuzio-Donahue CA, Massagué J. David CJ, et al. Cell. 2016 Feb 25;164(5):1015-30. doi: 10.1016/j.cell.2016.01.009. Epub 2016 Feb 18. Cell. 2016. PMID: 26898331 Free PMC article.

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