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Review
. 2016;13(1):13-21.
doi: 10.2174/1573406412666160229150803.

Cell-based Assays for Assessing Toxicity: A Basic Guide

Raveen Parboosing  1 , Gugulethu Mzobe, Louis Chonco, Indres Moodley
Affiliations
Review

Cell-based Assays for Assessing Toxicity: A Basic Guide

Raveen Parboosing et al. Med Chem. 2016.

Abstract

Assessment of toxicity is an important component of the drug discovery process. Cellbased assays are a popular choice for assessing cytotoxicity. However, these assays are complex because of the wide variety of formats and methods that are available, lack of standardization, confusing terminology and the inherent variability of biological systems and measurement. This review is intended as a guide on how to take these factors into account when planning, conducting and/or interpreting cell based toxicity assays.

Keywords: Cytotoxicity; apoptosis; cell-based assays; cytotoxicity screening; toxicity.; viability assays.

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