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. 2017 Mar;20(2):226-234.
doi: 10.1007/s10120-016-0603-7. Epub 2016 Feb 29.

A rising trend in the incidence of advanced gastric cancer in young Hispanic men

Shaila J Merchant  1 , Joseph Kim  2 , Audrey H Choi  3 , Virginia Sun  4 , Joseph Chao  5 , Rebecca Nelson  6
Affiliations

A rising trend in the incidence of advanced gastric cancer in young Hispanic men

Shaila J Merchant et al. Gastric Cancer. 2017 Mar.

Abstract

Background: Although the incidence of gastric cancer has been decreasing, recent reports suggest an increased rate in select populations. We sought to evaluate trends in gastric cancer incidence to identify high-risk populations.

Methods: Gastric cancer incidence rates from 1992 to 2011 were computed with use of the Surveillance, Epidemiology, and End Results (SEER) registry. We evaluated trends in incidence rates by calculating the annual percent change (APC) across three age groups (20-49 years, 50-64 years, and 65 years or older) and four racial/ethnic groups (Hispanics, non-Hispanic whites, blacks, and Asian/Pacific Islanders).

Results: We identified 41,428 patients with gastric cancer. For the entire cohort during the study period, the APC was decreased. When patients were grouped according to sex, the APC was flat or decreased in women regardless of age or race/ethnicity. The APC was also flat or decreased for all men except young Hispanic men (20-49 years), who had an increased APC of nearly 1.6 % (1.55 %, 95 % confidence interval 0.26-2.86 %). Furthermore, young Hispanic men were the only group to have increased incidence of stage IV disease (APC 4.34 %, 95 % confidence interval 2.76-5.94 %) and poorly differentiated tumors (APC 2.08 %, 95 % confidence interval 0.48-3.70 %).

Conclusions: The APC of the incidence of gastric cancer in young Hispanic men places it among the top cancers with rising incidence in the USA. This is concomitant with increased incidence of advanced disease at presentation. This major public health concern warrants additional research to determine the cause of the increasing incidence in this group.

Keywords: Advanced disease; Gastric cancer; Hispanic; Incidence.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors declare that they have no conflict of interest

Figures

Figure 1
Figure 1
Trends in gastric cancer incidence from 1992 to 2011 in the entire cohort (A) and then categorized by sex (B), age group (C) and race/ethnicity (D). *denotes significantly decreasing trend (*p<0.05, **p<0.01, ***p<0.001) compared to baseline.
Figure 1
Figure 1
Trends in gastric cancer incidence from 1992 to 2011 in the entire cohort (A) and then categorized by sex (B), age group (C) and race/ethnicity (D). *denotes significantly decreasing trend (*p<0.05, **p<0.01, ***p<0.001) compared to baseline.
Figure 1
Figure 1
Trends in gastric cancer incidence from 1992 to 2011 in the entire cohort (A) and then categorized by sex (B), age group (C) and race/ethnicity (D). *denotes significantly decreasing trend (*p<0.05, **p<0.01, ***p<0.001) compared to baseline.
Figure 1
Figure 1
Trends in gastric cancer incidence from 1992 to 2011 in the entire cohort (A) and then categorized by sex (B), age group (C) and race/ethnicity (D). *denotes significantly decreasing trend (*p<0.05, **p<0.01, ***p<0.001) compared to baseline.
Figure 2
Figure 2
Trends in gastric cancer incidence from 1992 to 2011 in young Hispanic males by stage (A), grade (B), tumor location (C) and geographical region (D). † denotes significantly increasing trend (†p<0.05, ††p<0.01, †††p<0.001) compared to baseline.
Figure 2
Figure 2
Trends in gastric cancer incidence from 1992 to 2011 in young Hispanic males by stage (A), grade (B), tumor location (C) and geographical region (D). † denotes significantly increasing trend (†p<0.05, ††p<0.01, †††p<0.001) compared to baseline.
Figure 2
Figure 2
Trends in gastric cancer incidence from 1992 to 2011 in young Hispanic males by stage (A), grade (B), tumor location (C) and geographical region (D). † denotes significantly increasing trend (†p<0.05, ††p<0.01, †††p<0.001) compared to baseline.
Figure 2
Figure 2
Trends in gastric cancer incidence from 1992 to 2011 in young Hispanic males by stage (A), grade (B), tumor location (C) and geographical region (D). † denotes significantly increasing trend (†p<0.05, ††p<0.01, †††p<0.001) compared to baseline.
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