Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Apr;38(3):e140-3.
doi: 10.1097/MPH.0000000000000528.

Identification and Clinical Characterization of Children With Benign Ethnic Neutropenia

Michael V Ortiz  1 , Emily R Meier, Matthew M Hsieh
Affiliations

Identification and Clinical Characterization of Children With Benign Ethnic Neutropenia

Michael V Ortiz et al. J Pediatr Hematol Oncol. 2016 Apr.

Abstract

Benign ethnic neutropenia (BEN) is an asymptomatic condition reported in adults of African and Middle Eastern descent. The clinical description in children is currently lacking. In our urban outpatient pediatric hematology clinic, the median neutrophil count of children with BEN was lower than previous reports in adults at 893×10 cells/L, but increased with older age. There was an equal male to female ratio and 24% of our BEN children reported ethnicities other than African or Middle Eastern. Children with BEN had a clinical course comparable with other healthy children including otherwise normal blood counts, except for mild anemia.

PubMed Disclaimer

References

    1. Hsieh MM, Everhart JE, Byrd-Holt DD, et al. Prevalence of neutropenia in the U.S. population: age, sex, smoking status, and ethnic differences. Ann Intern Med. 2007 Apr 3;146(7):486–92. - PubMed
    1. Denic S, Showqi S, Klein C, et al. Prevalence, phenotype and inheritance of benign neutropenia in Arabs. BMC Blood Disorders. 2009;9:3. doi:10.1186/1471-2326-9-3. - PMC - PubMed
    1. Paz Z, Nails M, Ziv E. The genetics of benign neutropenia. Isr Med Assoc J. 2011 Oct;13(10):625–9. - PubMed
    1. Mason BA, Lessin L, Schechter GP. Marrow granulocyte reserves in black Americans. Hydrocortisone-induced granulocytosis in the “benign” neutropenia of the black. Am J Med. 1979 Aug;67(2):201–5. - PubMed
    1. Mant M, Gordon P, Akabutu J. Bone marrow granulocyte reserve in chronic benign idiopathic neutropenia. Clin Lab Haematol. 1987;9(3):281–8. - PubMed