doi: 10.1007/BF00340709.
Mutations in ADE3 reduce the efficiency of the omnipotent suppressor sup45-2
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- PMID: 2692849
- DOI: 10.1007/BF00340709
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Mutations in ADE3 reduce the efficiency of the omnipotent suppressor sup45-2
Curr Genet.
1989 Dec.
Abstract
Mutations in a known yeast gene, ADE3, were shown to act as an antisuppressor, reducing the efficiency of the omnipotent suppressor, sup45-2. The ADE3 locus encodes the trifunctional enzyme C1-tetrahydrofolate synthase, which is required for the biosynthesis of purines, thymidylate, methionine, histidine, pantothenic acid and formylmethionyl-tRNA(fMet. The role of this enzyme in translational fidelity had not previously been suspected.
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