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. 1989 Dec;16(5-6):315-21.
doi: 10.1007/BF00340709.

Mutations in ADE3 reduce the efficiency of the omnipotent suppressor sup45-2

J M Song  1 , S W Liebman
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Mutations in ADE3 reduce the efficiency of the omnipotent suppressor sup45-2

J M Song et al. Curr Genet. 1989 Dec.

Abstract

Mutations in a known yeast gene, ADE3, were shown to act as an antisuppressor, reducing the efficiency of the omnipotent suppressor, sup45-2. The ADE3 locus encodes the trifunctional enzyme C1-tetrahydrofolate synthase, which is required for the biosynthesis of purines, thymidylate, methionine, histidine, pantothenic acid and formylmethionyl-tRNA(fMet. The role of this enzyme in translational fidelity had not previously been suspected.

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References

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