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. 2016 Mar 1:6:22271.
doi: 10.1038/srep22271.

Low T3 syndrome is a strong predictor of poor outcomes in patients with community-acquired pneumonia

Jinliang Liu  1 , Xuejie Wu  1 , Fang Lu  2 , Lifang Zhao  1 , Lingxian Shi  1 , Feng Xu  1
Affiliations

Low T3 syndrome is a strong predictor of poor outcomes in patients with community-acquired pneumonia

Jinliang Liu et al. Sci Rep. .

Abstract

Low T3 syndrome was previously reported to be linked to poor clinical outcomes in critically ill patients. The aim of this study was to evaluate the predictive power of low T3 syndrome for clinical outcomes in patients with community-acquired pneumonia (CAP). Data for 503 patients were analyzed retrospectively, and the primary end point was 30-day mortality. The intensive care unit (ICU) admission rate and 30-day mortality were 8.3% and 6.4% respectively. The prevalence of low T3 syndrome differed significantly between survivors and nonsurvivors (29.1% vs 71.9%, P < 0.001), and low T3 syndrome was associated with a remarkable increased risk of 30-day mortality and ICU admission in patients with severe CAP. Multivariate logistic regression analysis produced an odds ratio of 2.96 (95% CI 1.14-7.76, P = 0.025) for 30-day mortality in CAP patients with low T3 syndrome. Survival analysis revealed that the survival rate among CAP patients with low T3 syndrome was lower than that in the control group (P < 0.01). Adding low T3 syndrome to the PSI and CURB-65 significantly increased the areas under the ROC curves for predicting ICU admission and 30-day mortality. In conclusion, low T3 syndrome is an independent risk factor for 30-day mortality in CAP patients.

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Figures

Figure 1
Figure 1. Survival analysis for patients with or without low T3 syndrome.
Figure 2
Figure 2
ROC curves for FT3, FT4, and TSH for 30-day mortality (A) and ICU admission (B).
Figure 3
Figure 3
ROC curves for PSI and low FT3 + PSI for 30-day mortality (A) and ICU admission (B).
Figure 4
Figure 4
ROC curves for CURB-65 and low FT3 + CURB-65 for 30-day mortality (A) and ICU admission (B).
See this image and copyright information in PMC

References

    1. Almirall J. et al. Epidemiology of community-acquired pneumonia in adults: a population-based study. Eur Respir J. 15, 757–63 (2000). - PubMed
    1. Ewig S. et al. New perspectives on community-acquired pneumonia in 388406 patients. Results from a nationwide mandatory performance measurement programme in healthcare quality. Thorax. 64, 1062–9 (2009). - PMC - PubMed
    1. Woodhead M. et al. Guidelines for the management of adult lower respiratory tract infections. Eur Respir J. 26, 1138–80 (2005). - PubMed
    1. Restrepo M. I., Mortensen E. M., Velez J. A., Frei C. & Anzueto A. A comparative study of community-acquired pneumonia patients admitted to the ward and the ICU. Chest. 133, 610–7 (2008). - PubMed
    1. Yandiola P. P. et al. Prospective comparison of severity scores for predicting clinically relevant outcomes for patients hospitalized with community-acquired pneumonia. Chest. 135, 1572–1579 (2009). - PubMed

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