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Comment
. 2016 May;29(3):261-3.
doi: 10.1111/pcmr.12470.

Melanocytes in psoriasis: convicted culprit or bullied bystander?

James P Strassner, Mehdi Rashighi, John E Harris  1
Affiliations
Comment

Melanocytes in psoriasis: convicted culprit or bullied bystander?

James P Strassner et al. Pigment Cell Melanoma Res. 2016 May.
No abstract available

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Figures

Figure 1
Figure 1
The potential role of a melanocyte antigen within the complex psoriatic inflammatory pathway. T cells encounter the autoantigen ADAMTSL5 (yellow circle) in the skin, via melanocyte (MC) presentation on MHC I. TCR stimulation in the context of the psoriatic pro-inflammatory milieu may lead to enhanced IL-17 production by these cells; however, the functional significance of ADAMTSL5 specific T cells remains unknown. Higher IL-17 levels contribute to dysregulated KC proliferation and release of LL37, cytokines and chemokines (red arrows) that perpetuate the inflammatory response.
See this image and copyright information in PMC

Comment on

  • Melanocyte antigen triggers autoimmunity in human psoriasis.
    Arakawa A, Siewert K, Stöhr J, Besgen P, Kim SM, Rühl G, Nickel J, Vollmer S, Thomas P, Krebs S, Pinkert S, Spannagl M, Held K, Kammerbauer C, Besch R, Dornmair K, Prinz JC. Arakawa A, et al. J Exp Med. 2015 Dec 14;212(13):2203-12. doi: 10.1084/jem.20151093. Epub 2015 Nov 30. J Exp Med. 2015. PMID: 26621454 Free PMC article.

References

    1. Bader Hannah L., Wang Lauren W., Ho Jason C., Tran Thu, Holden Paul, Fitzgerald Jamie, Atit Radihika P., Reinhardt Dieter P., Apte SS, 2012. A Disintegrin-Like and Metalloprotease Domain Containing Thrombospondin Type 1 Motif-like 5 (ADAMTSL5) is a novel fibrillin-1-, fibrillin-2-, and heparin-binding member of the ADAMTS superfamily containing a netrin-like module. Matrix Biology, 31(7–8), pp.398–411. - PMC - PubMed
    1. Kim S-M et al., 2012. Analysis of the paired TCR α- and β-chains of single human T cells. PloS one, 7(5), p.e37338 Available at: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037338. - PMC - PubMed
    1. Lande R et al., 2014. The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis. Nature communications, 5(May), p.5621 Available at: http://www.ncbi.nlm.nih.gov/pubmed/25470744. - PubMed
    1. Lowes M. a., Suárez-Fariñas M & Krueger JG, 2014. Immunology of Psoriasis. Annual Review of Immunology, 32(1), pp.227–255. Available at: http://www.annualreviews.org/doi/abs/10.1146/annurev-immunol-032713-120225. - DOI - PMC - PubMed
    1. Rashigi Mehdi, Agarwal Priti, Richmond Jillian M., Harris Tajie H., Dresser Karen, Su Mingwan, Zhou Youwen, Deng April, Hunter Chris A., Luster Andrew D., Harris JE, 2014. CXCL10 is criticial for the progression and maintenance of depigmentation in a mouse model of vitiligo. Science translational medicine, 6(223), p.223ra23. - PMC - PubMed

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