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Comparative Study
. 2016 Feb 4:11:239-49.
doi: 10.2147/COPD.S84347. eCollection 2016.

Depression, body mass index, and chronic obstructive pulmonary disease - a holistic approach

Giuseppe Catalfo  1 , Luciana Crea  1 , Tiziana Lo Castro  1 , Francesca Magnano San Lio  1 , Giuseppe Minutolo  1 , Gherardo Siscaro  2 , Noemi Vaccino  1 , Nunzio Crimi  3 , Eugenio Aguglia  1
Affiliations
Comparative Study

Depression, body mass index, and chronic obstructive pulmonary disease - a holistic approach

Giuseppe Catalfo et al. Int J Chron Obstruct Pulmon Dis. .

Abstract

Background: Several clinical studies suggest common underlying pathogenetic mechanisms of COPD and depressive/anxiety disorders. We aim to evaluate psychopathological and physical effects of aerobic exercise, proposed in the context of pulmonary rehabilitation, in a sample of COPD patients, through the correlation of some psychopathological variables and physical/pneumological parameters.

Methods: Fifty-two consecutive subjects were enrolled. At baseline, the sample was divided into two subgroups consisting of 38 depression-positive and 14 depression-negative subjects according to the Hamilton Depression Rating Scale (HAM-D). After the rehabilitation treatment, we compared psychometric and physical examinations between the two groups.

Results: The differences after the rehabilitation program in all assessed parameters demonstrated a significant improvement in psychiatric and pneumological conditions. The reduction of BMI was significantly correlated with fat mass but only in the depression-positive patients.

Conclusion: Our results suggest that pulmonary rehabilitation improves depressive and anxiety symptoms in COPD. This improvement is significantly related to the reduction of fat mass and BMI only in depressed COPD patients, in whom these parameters were related at baseline. These findings suggest that depressed COPD patients could benefit from a rehabilitation program in the context of a multidisciplinary approach.

Keywords: BMI; COPD; aerobic exercise; depression.

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Figures

Figure 1
Figure 1
Scatterplot of absolute variations of HAM-D and fat mass from baseline to 3 months in the total sample of patients with COPD in a pulmonary rehabilitation program. Abbreviation: HAM-D, Hamilton Depression Rating Scale.
Figure 2
Figure 2
Scatterplot of absolute variations of HAM-D and BMI from baseline to 3 months in the total sample of patients with COPD in a pulmonary rehabilitation program. Abbreviations: BMI, body mass index; HAM-D, Hamilton Depression Rating Scale.
Figure 3
Figure 3
Scatterplot of absolute variations of fat mass and HADS-D from baseline to 3 months in the depression-positive subgroup of patients with COPD in a pulmonary rehabilitation program. Abbreviation: HADS-D, Hospital Anxiety and Depression Scale, depression subscale.
Figure 4
Figure 4
Scatterplot of absolute variations of fat mass and HADS-A from baseline to 3 months in the depression-positive subgroup of patients with COPD in a pulmonary rehabilitation program. Abbreviation: HADS-A, Hospital Anxiety and Depression Scale, anxiety subscale.
Figure 5
Figure 5
Scatterplot of absolute variations of BMI and HADS-A from baseline to 3 months in the depression-positive subgroup of patients with COPD in a pulmonary rehabilitation program. Abbreviations: BMI, body mass index; HADS-A, Hospital Anxiety and Depression Scale, anxiety subscale.
Figure 6
Figure 6
Scatterplot of absolute variations of BMI and HADS-D from baseline to 3 months in the depression-positive subgroup of patients with COPD in a pulmonary rehabilitation program. Abbreviations: BMI, body mass index; HADS-D, Hospital Anxiety and Depression Scale, depression subscale.
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References

    1. Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study. Lancet. 1997;349:1498–1504. - PubMed
    1. Lopez AD, Murray CC. The global burden of disease, 1990–2020. Nat Med. 1998;4:1241–1243. - PubMed
    1. Celli BR, Pauwels R, Snider GL. Standards for the Diagnosis and Management of Patients with COPD. New York: American Thoracic Society; Lausanne: European Respiratory Society; 2004. Definition, diagnosis and staging; pp. 8–13.
    1. Janson C, Björnsson E, Hetta J, Boman G. Anxiety and depression in relation to respiratory symptoms and asthma. Am J Respir Crit Care Med. 1994;149:930–934. - PubMed
    1. Di Marco F, Verga M, Reggente M, et al. Anxiety and depression in COPD patients: the roles of gender and disease severity. Respir Med. 2006;100(10):1767–1774. - PubMed

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