Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2016 Feb 9:9:25-8.
doi: 10.2147/IMCRJ.S88494. eCollection 2016.

Malignant melanoma of the nasal septum, a rare tumor, occurring in a 54-year-old patient after hereditary retinoblastoma treatment

Windinmanégdé Pierre Djiguimdé  1 , Ibrahim Abib Diomandé  2 , Nicolas Bonnin  3 , Nicolas Saroul  4 , Abdoulaye Touré  5 , Jérôme Sanou  1 , Paté Sankara  1 , Marc Russier  4 , Laurent Gilain  4 , Ahgbatouhabéba Ahnoux-Zabsonré  1 , Nonfounikoun Meda  1 , Franck Bacin  3
Affiliations
Case Reports

Malignant melanoma of the nasal septum, a rare tumor, occurring in a 54-year-old patient after hereditary retinoblastoma treatment

Windinmanégdé Pierre Djiguimdé et al. Int Med Case Rep J. .

Abstract

The authors report a case of a malignant melanoma of the nasal cavity that is a rare tumor and very aggressive, constituting 1% of all melanomas. It appeared in a patient 54 years after he was treated for a hereditary retinoblastoma. Its symptoms are nonspecific, and often marked by epistaxis. Its diagnosis is histological, supported by immunohistochemistry. Its prognosis is often unfavorable, and characterized by the occurrence of metastases and recurrences. Because of the risk of secondary cancer that exists in any survivor of hereditary retinoblastoma, we must think of possible mucosal melanoma of the nasal sinus in these patients in cases of chronic epistaxis. The prognosis of this tumor depends on its early diagnosis and surgical treatment.

Keywords: epistaxis; hereditary cancer; immunohistochemistry; nasosinusal melanoma; retinoblastoma.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Preoperative CT scan showing the nasal tumor. Notes: (A) Axial computed tomography scan of sinus with a parenchymal opening; (B) coronal bone with an opening showing a thickening tissue of the right nasal cavity.
Figure 2
Figure 2
Infiltration of the right nasal cavity wall with a melanoma arriving in depth to the cartilage without invading it. Notes: Hematoxylin-eosin-saffron staining (magnification × 2). Image courtesy of JL Kemeny. Abbreviation: hematoxylin-eosin-saffron.
Figure 3
Figure 3
Detail of tumor melanoma cells that have an atypical nucleus. Note: Image courtesy of JL Kemeny.
Figure 4
Figure 4
Brown marking of intracytoplasmic tumor cells with HMB45 and melan A in immunohistochemistry on paraffin section (magnification ×40). Note: Image courtesy of JL Kemeny.
Figure 5
Figure 5
Postoperative computed tomography showing empty nasal cavities.
See this image and copyright information in PMC

References

    1. Desjardins L, Couturier J, Doz F, Gauthiers-Vilars M, Sastre X. Encycl Med Chir Ophthalmologie. Paris: Elsevier SAS; 2004. Tumeurs de la rétine. 2003. [Retinoblastoma 2003.] pp. 18–37. French.
    1. Doz F. Rétinoblastome: aspects récents. [Retinoblatoma: a review] Arch Pediatr. 2006;13:1329–1337. French. - PubMed
    1. Castéra L, Sabbagh A, Dehainault C, et al. MDM2 as a modifier gene in retinoblastoma. J Natl Cancer Inst. 2010;102:1805–1808. - PubMed
    1. Zografos L. Tumeurs Intraoculaires [Intraocular Tumors] Paris: Editions Masson; 2002. Rétinoblastome [Retinoblastoma] pp. 463–619. French.
    1. Desjardins L. Les tumeurs en ophtalmo-pédiatrie. Diagnostic et stratégie thérapeutique. [Ophthalmological tumors in children: diagnosis and therapeutic strategy] J Fr Ophtalmol. 2000;23:926–939. French. - PubMed

Publication types

LinkOut - more resources