Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2016 Feb 3;12(3):270-2.
doi: 10.7150/ijbs.14950. eCollection 2016.

Pancreatic Cancer: Current Progress and Future Challenges

S Perwez Hussain  1
Affiliations
Editorial

Pancreatic Cancer: Current Progress and Future Challenges

S Perwez Hussain. Int J Biol Sci. .

Abstract

Pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer, remains one of the highly lethal malignancies. The highly refractory nature of clinically advanced disease and lack of a reliable biomarker for early detection are major obstructions in improving patient outcome. The recent efforts, however, in understanding the pancreatic tumor biology have resulted in the recognition of novel addictions as well as vulnerabilities of tumor cells and are being assessed for their clinical potential. This special issue highlights some of the recent progress, complexity and challenges towards improving disease outcome in patients with this lethal malignancy.

Keywords: Pancreatic Cancer.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Recent advances in understanding pancreatic tumor biology and the underlying mechanism of disease aggressiveness are providing clues, which may help to potentially improve diagnosis, treatment and patient outcome. Some of the critical biological determinants in the development and progression of pancreatic cancer have been reviewed in this special issue.
See this image and copyright information in PMC

References

    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65:5–29. - PubMed
    1. Provenzano PP, Cuevas C, Chang AE. et al. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell. 2012;21:418–29. - PMC - PubMed
    1. Goggins M. Markers of pancreatic cancer: working toward early detection. Clin Cancer Res. 2011;17:635–7. - PMC - PubMed
    1. Stromnes IM, Schmitt TM, Hulbert A. et al. T Cells Engineered against a Native Antigen Can Surmount Immunologic and Physical Barriers to Treat Pancreatic Ductal Adenocarcinoma. Cancer Cell. 2015;28:638–52. - PMC - PubMed
    1. Vincent A, Herman J, Schulick R. et al. Pancreatic cancer. Lancet. 2011;378:607–20. - PMC - PubMed

Publication types

MeSH terms