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Review
. 2016 Apr;12(2):147-50.
doi: 10.3988/jcn.2016.12.2.147. Epub 2016 Feb 26.

Association between Parkinson's Disease and Helicobacter Pylori

Gülşah Çamcı  1 , Sıdıka Oğuz  2
Affiliations
Review

Association between Parkinson's Disease and Helicobacter Pylori

Gülşah Çamcı et al. J Clin Neurol. 2016 Apr.

Abstract

Helicobacter pylori (HP) is a common infection of the gastrointestinal system that is usually related to peptic ulcers. However, recent studies have revealed relationships between HP and many other diseases. Although the exact mechanism is unknown, HP can prevent the absorption of certain drugs. A high prevalence of HP has been found in patients with Parkinson's disease, and this bacterium causes motor fluctuations by affecting the absorption of levodopa, which is the main drug used to treat Parkinson's disease. Eradicating HP from patients with Parkinson's disease by applying antibiotic treatment will increase the absorption of levodopa and decrease their motor fluctuations.

Keywords: Helicobacter pylori; Parkinson's disease; levodopa; motor fluctuations.

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Conflict of interest statement

Conflicts of Interest: The authors have no financial conflicts of interest.

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