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Case Reports
. 2016 Mar;31(2):399-402.
doi: 10.3904/kjim.2014.283. Epub 2016 Feb 26.

Painful immunoglobulin G4-related thyroiditis treated by total thyroidectomy

Ihn Suk Lee  1 , Jung Uee Lee  2 , Kwan-Ju Lee  3 , Yi Sun Jang  1 , Jong Min Lee  1 , Hye Soo Kim  1
Affiliations
Case Reports

Painful immunoglobulin G4-related thyroiditis treated by total thyroidectomy

Ihn Suk Lee et al. Korean J Intern Med. 2016 Mar.
No abstract available

Keywords: Hashimoto thyroiditis; IgG4-related disease; Immunoglobulin G.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1.
Figure 1.
Thyroid scan. (A) Thyroid scan showing diffuse goiter with increased radionuclide uptake in October 2011. (B) Thyroid scan showing multiple hot uptakes with intervening low uptakes in January 2013.
Figure 2.
Figure 2.
Ultrasound image of the right thyroid lobe. (A) Thyroid ultrasonography showed only diffuse coarse echogenicity in October 2011. (B) A low-echoic area was observed in March 2012. (C) The low-echoic area encroached in June 2012. (D) The low-echoic area finally expanded to encompass nearly the entire lobe in January 2013.
Figure 3.
Figure 3.
Pathological findings of the resected thyroid gland. (A) High-power view showing massive lymphocyte and plasmocyte infiltration and fibrosis among destructive follicles, including oncocytic follicular cells (H&E, ×400). (B) Phlebitis is observed (H&E, ×400). (C) Low-power view showing thickening of the thyroid capsule with extracapsular fibrosis (H&E, ×100). (D) Immunohistochemical stain of immunoglobulin G4 (IgG4; 1:2,000 dilution, Abcam, UK) reveals multiple IgG4-positive plasma cells (×200)
See this image and copyright information in PMC

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References

    1. Li Y, Nishihara E, Hirokawa M, Taniguchi E, Miyauchi A, Kakudo K. Distinct clinical, serological, and sonographic characteristics of hashimoto’s thyroiditis based with and without IgG4-positive plasma cells. J Clin Endocrinol Metab. 2010;95:1309–1317. - PubMed
    1. Zhang J, Zhao L, Gao Y, et al. A classification of Hashimoto’s thyroiditis based on immunohistochemistry for IgG4 and IgG. Thyroid. 2014;24:364–370. - PubMed
    1. Xie LD, Gao Y, Li MR, Lu GZ, Guo XH. Distribution of immunoglobulin G subclasses of anti-thyroid peroxidase antibody in sera from patients with Hashimoto’s thyroiditis with different thyroid functional status. Clin Exp Immunol. 2008;154:172–176. - PMC - PubMed
    1. Papi G, LiVolsi VA. Current concepts on Riedel thyroiditis. Am J Clin Pathol. 2004;121 Suppl:S50–S63. - PubMed
    1. Kim HK, Shin HJ, Kang HC. A case of painful Hashimoto’s thyroiditis successfully treated with total thyroidectomy. J Korean Endocr Soc. 2008;23:438–443.

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