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Comment
. 2016 Apr;13(4):187-8.
doi: 10.1038/nrcardio.2016.27. Epub 2016 Mar 3.

Arrhythmias: Opening Pandora's Box -- incidental genetic findings

Elijah R Behr  1 , Andrew D Krahn  2
Affiliations
Comment

Arrhythmias: Opening Pandora's Box -- incidental genetic findings

Elijah R Behr et al. Nat Rev Cardiol. 2016 Apr.

Abstract

A major goal of precision medicine is to improve disease prevention and therapy by using big data provided by genomic technology and electronic health records. In a new study, assessment of a patient population without a history of cardiac disease revealed that genetic variants putatively associated with a risk of sudden death were not linked with arrhythmia phenotypes.

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Comment on

  • Association of Arrhythmia-Related Genetic Variants With Phenotypes Documented in Electronic Medical Records.
    Van Driest SL, Wells QS, Stallings S, Bush WS, Gordon A, Nickerson DA, Kim JH, Crosslin DR, Jarvik GP, Carrell DS, Ralston JD, Larson EB, Bielinski SJ, Olson JE, Ye Z, Kullo IJ, Abul-Husn NS, Scott SA, Bottinger E, Almoguera B, Connolly J, Chiavacci R, Hakonarson H, Rasmussen-Torvik LJ, Pan V, Persell SD, Smith M, Chisholm RL, Kitchner TE, He MM, Brilliant MH, Wallace JR, Doheny KF, Shoemaker MB, Li R, Manolio TA, Callis TE, Macaya D, Williams MS, Carey D, Kapplinger JD, Ackerman MJ, Ritchie MD, Denny JC, Roden DM. Van Driest SL, et al. JAMA. 2016 Jan 5;315(1):47-57. doi: 10.1001/jama.2015.17701. JAMA. 2016. PMID: 26746457 Free PMC article.

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