Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Apr;12(4):195-6.
doi: 10.1038/nrrheum.2016.24. Epub 2016 Mar 3.

Connective tissue diseases: Mitochondria drive NETosis and inflammation in SLE

Eric Boilard  1 , Paul R Fortin  2
Affiliations
Comment

Connective tissue diseases: Mitochondria drive NETosis and inflammation in SLE

Eric Boilard et al. Nat Rev Rheumatol. 2016 Apr.

Abstract

Mitochondria are the powerhouses of the cell, providing energy through oxidative respiration. Possibly owing to their similarities with bacteria, however, mitochondria extruded from cells promote inflammation. New research demonstrates that in systemic lupus erythematosus, mitochondrial respiration is critical in neutrophil extracellular trap formation, and that mitochondria released by neutrophils induce inflammatory cytokine production.

PubMed Disclaimer

Comment on

References

    1. Blood. 2009 Sep 24;114(13):2619-22 - PubMed
    1. Nat Rev Rheumatol. 2011 Sep 27;7(12):691-9 - PubMed
    1. J Immunol. 2011 Jul 1;187(1):538-52 - PubMed
    1. Nature. 1998 Nov 12;396(6707):133-40 - PubMed
    1. Blood. 2014 Oct 2;124(14):2173-83 - PubMed

Substances

LinkOut - more resources