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Comment
. 2016 Mar 2;89(5):881-4.
doi: 10.1016/j.neuron.2016.02.022.

Inside Out: Core Network of Transcription Factors Drives Axon Regeneration

Choya Yoon  1 , Roman J Giger  2
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Inside Out: Core Network of Transcription Factors Drives Axon Regeneration

Choya Yoon et al. Neuron. .
Free article

Abstract

In this issue, Chandran et al. (2016) pursue a multi-level bioinformatics approach combined with wet bench validation to identify gene networks associated with the regenerative state of injured adult sensory neurons. A small molecular compound, ambroxol, mimics aspects of the identified gene expression patterns and promotes axon regeneration in the injured adult mouse CNS, demonstrating feasibility of in silico-based methods to identify compounds that promote neuronal growth following CNS injury.

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  • A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program.
    Chandran V, Coppola G, Nawabi H, Omura T, Versano R, Huebner EA, Zhang A, Costigan M, Yekkirala A, Barrett L, Blesch A, Michaelevski I, Davis-Turak J, Gao F, Langfelder P, Horvath S, He Z, Benowitz L, Fainzilber M, Tuszynski M, Woolf CJ, Geschwind DH. Chandran V, et al. Neuron. 2016 Mar 2;89(5):956-70. doi: 10.1016/j.neuron.2016.01.034. Epub 2016 Feb 18. Neuron. 2016. PMID: 26898779 Free PMC article.

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