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Randomized Controlled Trial
. 2016 Jun;46(7):439-45.
doi: 10.1016/j.ijpara.2016.01.006. Epub 2016 Mar 2.

Impact of two rounds of praziquantel mass drug administration on Schistosoma mansoni infection prevalence and intensity: a comparison between community wide treatment and school based treatment in western Kenya

Isaac O Onkanga  1 , Pauline N M Mwinzi  1 , Geoffrey Muchiri  1 , Kennedy Andiego  1 , Martin Omedo  1 , Diana M S Karanja  1 , Ryan E Wiegand  2 , W Evan Secor  3 , Susan P Montgomery  2
Affiliations
Randomized Controlled Trial

Impact of two rounds of praziquantel mass drug administration on Schistosoma mansoni infection prevalence and intensity: a comparison between community wide treatment and school based treatment in western Kenya

Isaac O Onkanga et al. Int J Parasitol. 2016 Jun.

Abstract

This study compared the effectiveness of the community-wide treatment and school-based treatment approaches in the control of Schistosoma mansoni infections in villages with ⩾25% prevalence in western Kenya. Stool samples from first year students, 9-12year olds and adults (20-55years) were analyzed by the Kato-Katz technique for S. mansoni eggs. After two rounds of treatment, S. mansoni prevalence and intensity levels significantly declined in both treatment approaches. Prevalence comparisons between the two approaches did not show any significant differences following treatment. However, infection intensity levels in the 9-12year old school-attending pupils were significantly higher in the community-wide treatment arm than in the school-based treatment arm. Nevertheless, significant reductions in S. mansoni infection prevalence and intensity levels were achieved among school-age children regardless of the treatment approach used.

Keywords: Community wide treatment; Mass drug administration; Praziquantel; Prevalence; Schistosoma mansoni; Schistosomiasis; School based treatment.

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Figures

None
Graphical abstract
Fig. 1
Fig. 1
Schistosomiasis Consortium for Operational Research and Evaluation study design. Communities were randomised into six intervention arms. CWT, community-wide treatment; SBT, school-based treatment. ND, not done, indicating that stool samples were not collected for that arm because there was no treatment scheduled for that year.
See this image and copyright information in PMC

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