doi: 10.1073/pnas.74.8.3466.
Addition of colchicine--tubulin complex to microtubule ends: the mechanism of substoichiometric colchicine poisoning
- PMID: 269406
- PMCID: PMC431611
- DOI: 10.1073/pnas.74.8.3466
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Addition of colchicine--tubulin complex to microtubule ends: the mechanism of substoichiometric colchicine poisoning
Proc Natl Acad Sci U S A.
1977 Aug.
Abstract
Colchicine blocks microtubule polymerization by an unusual substoichiometric poisoning mechanism. We have investigated the mechanism by which this poisoning occurs with several experimental approaches, and have found that colchicine acts by addition to microtubule ends as a colchicine-tubulin complex.
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