Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Oct;18(10):1022-1026.
doi: 10.1111/jch.12801. Epub 2016 Mar 4.

Serum Beta-Trace Protein as a Novel Predictor of Pregnancy-Induced Hypertension

Bide Duan  1   2 , Lei Zhang  3 , Xiaoyan Ding  2 , Ling Li  4 , Yuan Li  2 , Hui Geng  2 , Yuyan Ma  5
Affiliations

Serum Beta-Trace Protein as a Novel Predictor of Pregnancy-Induced Hypertension

Bide Duan et al. J Clin Hypertens (Greenwich). 2016 Oct.

Abstract

Beta-trace protein (BTP) has emerged as a novel biomarker of cardiovascular risk. However, the level of circulating BTP in pregnancy-induced hypertension (PIH) is still unknown. The aim of this study was to determine the concentration of serum BTP in healthy pregnant women and patients with PIH. No significant difference was found in the serum concentration of BTP in patients with a normal pregnancy. In contrast, serum BTP levels in women with PIH (n=46) were significantly higher than those in women with normal pregnancy (n=57). Receiver operating characteristic analysis revealed that using a serum BTP value of 321.3 ng/mL as a cutoff produced a sensitivity of 91.3% and a specificity of 89.5%. Taken together, these findings suggest that a higher serum BTP concentration in PIH patients compared with those with normal pregnancy and serum BTP might be a novel biomarker in the diagnosis of PIH.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Serum beta‐trace protein (BTP) concentration was measured in serum from women with a normal pregnancy (n=57) and those with pregnancy‐induced hypertension (PIH) (n=46) during the first, second, and third trimester. Data are presented as mean±standard deviation. Significant differences were seen between patients with a normal pregnancy and those with PIH. **P<.01.
Figure 2
Figure 2
Serum beta‐trace protein (BTP) values in women with a normal pregnancy and those with pregnancy‐induced hypertension (PIH) were used to draw receiver operating characteristic (ROC) curves. Specificity, sensitivity, and area under the ROC curve were determined.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Roberts JM, Bodnar LM, Patrick TE, Powers RW. The role of obesity in preeclampsia. Pregnancy Hypertens. 2011;1:6–16. - PMC - PubMed
    1. Seely EW, Solomon CG. Insulin resistance and its potential role in pregnancy‐induced hypertension. J Clin Endocrinol Metab. 2003;88:2393–2398. - PubMed
    1. Greenwood JP, Scott EM, Walker JJ, et al. The magnitude of sympathetic hyperactivity in pregnancy‐induced hypertension and preeclampsia. Am J Hypertens. 2003;16:194–199. - PubMed
    1. Wolf M, Kettyle E, Sandler L, et al. Obesity and preeclampsia: the potential role of inflammation. Obstet Gynecol. 2001;98:757–762. - PubMed
    1. Lambert GW, Straznicky NE, Lambert EA, et al. Sympathetic nervous activation in obesity and the metabolic syndrome–causes, consequences and therapeutic implications. Pharmacol Ther. 2010;126:159–172. - PubMed

LinkOut - more resources