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. 1977 Aug;74(8):3550-4.
doi: 10.1073/pnas.74.8.3550.

Fatty liver induced in Zucker "fatty" (ff) rats by a semisynthetic diet rich in sucrose

P M Novikoff

Fatty liver induced in Zucker "fatty" (ff) rats by a semisynthetic diet rich in sucrose

P M Novikoff. Proc Natl Acad Sci U S A. 1977 Aug.

Abstract

A new fatty liver model is described in which heredity plays a major role. A marked fatty liver develops when the homozygous mutant Zucker rat (ff or "fatty") is fed a semi-synthetic diet enriched in sucrose. Lean littermates do not develop fatty livers on this experimental diet. Even old ff rats do not develop fatty livers on chow; the experimental diet is required. The fatty liver is described, including light microscopic and preliminary electron microscopic observations.

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