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Comment
. 2016 Mar 4;118(5):783-5.
doi: 10.1161/CIRCRESAHA.115.308103.

c-kit+ Cardiac Stem Cells: Spontaneous Creation or a Perplexing Reality

Mohsin Khan  1 , Walter J Koch  1
Affiliations
Comment

c-kit+ Cardiac Stem Cells: Spontaneous Creation or a Perplexing Reality

Mohsin Khan et al. Circ Res. .

Abstract

One of the lingering controversies in the field of cardiac regenerative medicine has been around the origin of c-kit+ cardiac stem cells in the heart and their contribution towards cardiac homeostasis. A recent study reports that a subpopulation of c-kit+ cardiac progenitors emerges from the cardiac neural crest (CNC) with the capacity to give rise to cardiomyocytes. Contribution of CNC derived c-kit+ cells to cardiac myocyte development is regulated by bone morphogenetic protein (BMP). However, ex vivo manipulation of CNCc-kit cells reveals efficient transformation to early cardiac progenitors.

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  • cKit+ cardiac progenitors of neural crest origin.
    Hatzistergos KE, Takeuchi LM, Saur D, Seidler B, Dymecki SM, Mai JJ, White IA, Balkan W, Kanashiro-Takeuchi RM, Schally AV, Hare JM. Hatzistergos KE, et al. Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):13051-6. doi: 10.1073/pnas.1517201112. Epub 2015 Oct 5. Proc Natl Acad Sci U S A. 2015. PMID: 26438843 Free PMC article.

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