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. 2016 Jan;51(1):14-17.
doi: 10.1097/NT.0000000000000138. Epub 2016 Feb 23.

Is Vitamin D Inadequacy in Early Life an Instance of the "Barker Hypothesis"?

Robert P Heaney  1
Affiliations

Is Vitamin D Inadequacy in Early Life an Instance of the "Barker Hypothesis"?

Robert P Heaney. Nutr Today. 2016 Jan.
No abstract available

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Conflict of interest statement

The author has no conflicts of interest to disclose.

Figures

FIGURE 1
FIGURE 1
Plot of the ratio of observed to expected cases of multiple sclerosis by birth month, redrawn from the work of Willer et al. Data points are means ± 2 SEM. The dashed line is the sine-curve fit to the data, showing the seasonal variation predicted for a phenomenon exhibiting a 12-month cycle of expression. (Copyright Robert P. Heaney, MD, 2015. Used with permission.)
FIGURE 2
FIGURE 2
Schematic diagram delineating the multiyear gap from perinatal exposure to later-life expression of the several adult-onset disorders described in this review. A denotes the group of earlier-onset disorders, for example, learning disabilities; B denotes those with a more delayed onset, for example, multiple sclerosis, schizophrenia, and juvenile diabetes; and C, the later-onset disorders, for example, preeclampsia and DM1. (Copyright Robert P. Heaney, M.D., 2015. Used with permission.)
See this image and copyright information in PMC

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