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Review
. 2016 Feb 24:7:220.
doi: 10.3389/fmicb.2016.00220. eCollection 2016.

Surface Proteoglycans as Mediators in Bacterial Pathogens Infections

Beatriz García  1 , Jesús Merayo-Lloves  2 , Carla Martin  1 , Ignacio Alcalde  3 , Luis M Quirós  1 , Fernando Vazquez  4
Affiliations
Review

Surface Proteoglycans as Mediators in Bacterial Pathogens Infections

Beatriz García et al. Front Microbiol. .

Abstract

Infectious diseases remain an important global health problem. The interaction of a wide range of pathogen bacteria with host cells from many different tissues is frequently mediated by proteoglycans. These compounds are ubiquitous complex molecules which are not only involved in adherence and colonization, but can also participate in other steps of pathogenesis. To overcome the problem of microbial resistance to antibiotics new therapeutic agents could be developed based on the characteristics of the interaction of pathogens with proteoglycans.

Keywords: bacteria; glycosaminoglycans; host interaction; infection; proteoglycans.

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Figures

FIGURE 1
FIGURE 1
Repeating disaccharide units of GAGs.
FIGURE 2
FIGURE 2
Heparan sulfate (HS) domain architecture. The highly sulfated NS-domains are flanked on either side by less-sulfated transition zones (NA/NS). In turn, these sulphated regions are separated by non-sulfated NA-domains.
FIGURE 3
FIGURE 3
Adhesion of bacterium to target cells mediated by HS and shedding of syndecan ectodomains. Schematic representation of the interaction between an adhesin on the outer membrane of a Gram negative bacteria and HS from syndecan on the cell surface of a eukaryotic.
See this image and copyright information in PMC

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