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. 2015 Aug 12;5(1):e1068495.
doi: 10.1080/2162402X.2015.1068495. eCollection 2016.

Targeting TNF alpha as a novel strategy to enhance CD8+ T cell-dependent immune response in melanoma?

Florie Bertrand  1 , Julia Rochotte  2 , Céline Colacios  2 , Anne Montfort  3 , Nathalie Andrieu-Abadie  1 , Thierry Levade  2 , Hervé Benoist  2 , Bruno Ségui  2
Affiliations

Targeting TNF alpha as a novel strategy to enhance CD8+ T cell-dependent immune response in melanoma?

Florie Bertrand et al. Oncoimmunology. .

Abstract

Tumor Necrosis Factor α (TNF) is a pleiotropic cytokine exhibiting a dual activity in oncoimmunology, either acting as a cytotoxic effector produced by leukocytes or behaving as an immunosuppressive molecule. We have just discovered that TNF signaling impairs the accumulation of tumor-infiltrating CD8+ T lymphocytes in experimental melanoma.

Keywords: Apoptosis; T lymphocytes; TNF; high endothelial venules; melanoma; tumor-infiltrating CD8+ lymphocytes.

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Figures

Figure 1.
Figure 1.
TNF impairs CD8+ TIL accumulation in melanoma. TNF-R1-dependent TNF signaling (i) limits the intra-tumor content of HEV, which are involved in lymphocyte extravasation, and (ii) induces activated CD8+ T cell death, thus facilitating melanoma escape from the immune system.
See this image and copyright information in PMC

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