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. 2016 Sep;86(5):789-95.
doi: 10.2319/100415-663.1. Epub 2016 Mar 4.

In vitro biocompatibility of nickel-titanium esthetic orthodontic archwires

Roberto Rongo  1 , Rosa Valletta  2 , Rosaria Bucci  1 , Virginia Rivieccio  3 , Angela Galeotti  4 , Ambrosina Michelotti  5 , Vincenzo D'Antò  6
Affiliations

In vitro biocompatibility of nickel-titanium esthetic orthodontic archwires

Roberto Rongo et al. Angle Orthod. 2016 Sep.

Abstract

Objective: To investigate the cytotoxicity of nickel-titanium (NiTi) esthetic orthodontic archwires with different surface coatings.

Materials and methods: Three fully coated, tooth-colored NiTi wires (BioCosmetic, Titanol Cosmetic, EverWhite), two ion-implanted wires (TMA Purple, Sentalloy High Aesthetic), five uncoated NiTi wires (BioStarter, BioTorque, Titanol Superelastic, Memory Wire Superelastic, and Sentalloy), one β-titanium wire (TMA), and one stainless steel wire (Stainless Steel) were considered for this study. The wire samples were placed at 37°C in airtight test tubes containing Dulbecco's Modified Eagle's Medium (0.1 mg/mL) for 1, 7, 14, and 30 days. The cell viability of human gingival fibroblasts (HGFs) cultured with this medium was assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Data were analyzed by a two-way analysis of variance (α = .05).

Results: The highest cytotoxic effect was reached on day 30 for all samples. The archwires exhibited a cytotoxicity on HGFs ranging from "none" to "slight," with the exception of the BioTorque, which resulted in moderate cytotoxicity on day 30. Significant differences were found between esthetic archwires and their uncoated pairs only for BioCosmetic (P = .001) and EverWhite (P < .001).

Conclusions: Under the experimental conditions, all of the NiTi esthetic archwires resulted in slight cytotoxicity, as did the respective uncoated wires. For this reason their clinical use may be considered to have similar risks to the uncoated archwires.

Keywords: Biocompatibility; Coated wires; Esthetic archwires; Orthodontics.

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Comment in

  • Letters From Our Readers.
    Rongo R, Valletta R, Bucci R, Rivieccio V, Galeotti A, Michelotti A, D'Antò V. Rongo R, et al. Angle Orthod. 2017 May;87(3):486. doi: 10.2319/0003-3219-87.3.486. Angle Orthod. 2017. PMID: 28426323 Free PMC article. No abstract available.
  • Letters From Our Readers.
    Freitas MPM. Freitas MPM. Angle Orthod. 2017 May;87(3):485. doi: 10.2319/0003-3219-87.3.485. Angle Orthod. 2017. PMID: 28426324 Free PMC article. No abstract available.

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