Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016:21:70-2.
doi: 10.1016/j.ijscr.2016.02.031. Epub 2016 Mar 2.

Pancreatic manifestations in von Hippel-Lindau disease: A case report

Subhashini Ayloo  1 , Michele Molinari  2
Affiliations

Pancreatic manifestations in von Hippel-Lindau disease: A case report

Subhashini Ayloo et al. Int J Surg Case Rep. 2016.

Abstract

Introduction: Pancreatic manifestations in Von Hippel-Lindau (VHL) disease can present as a multitude of forms, and their management can be challenging.

Presentation of the case: A 66-year-old woman presented with increasing abdominal girth without other associated symptoms of nausea, vomiting, abdominal pain, weight-loss, and jaundice. Her medical and surgical histories were significant for type II diabetes, cerebral tumor resection, bilateral nephrectomies, and laser photocoagulation of retinal hemangiomas. Computed tomography (CT) of the abdomen showed a massive multi-cystic lesion in the pancreas and the patient was referred to our hepatopancreatic biliary center.

Discussion: The findings on the subsequent cross-sectional MRI imaging signified pancreatic manifestations in VHL disease.

Conclusion: The management of VHL disease-associated benign pancreatic cystic lesions involves interval monitoring with cross-sectional imaging for malignant changes/development.

Keywords: Case report; Pancreatic cyst; Pancreatic neuroendocrine tumor; Serous cystadenoma; Von Hippel–Lindau disease.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Magnetic resonance imaging of abdomen (panel A–D). Arrow head: multiple pancreatic cysts; single arrow: benign simple cysts; oval arrow: serous cystadenomas.
See this image and copyright information in PMC

References

    1. Kunzli B.M., Shrikhande S.V., Buchler M.W., Friess H. Pancreatic lesions in von Hippel–Lindau syndrome: report of a case. Surg. Today. 2004;34(7):626–629. - PubMed
    1. Delman K.A., Shapiro S.E., Jonasch E.W., Lee J.E., Curley S.A., Evans D.B. Abdominal visceral lesions in von Hippel–Lindau disease: incidence and clinical behavior of pancreatic and adrenal lesions at a single center. World J. Surg. 2006;30(May (5)):665–669. - PubMed
    1. CARE Checklist, 2016 (cited 18.02.16). Available from: http://www.care-statement.org/care-checklist.html.
    1. Charlesworth M., Verbeke C.S., Falk G.A., Walsh M., Smith A.M., Morris-Stiff G. Pancreatic lesions in von Hippel–Lindau disease? A systematic review and meta-synthesis of the literature. J. Gastrointest. Surg. 2012;16(July (7)):1422–1428. - PubMed
    1. Tamura K., Nishimori I., Ito T., Yamasaki I., Igarashi H., Shuin T. Diagnosis and management of pancreatic neuroendocrine tumor in von Hippel–Lindau disease. World J. Gastroenterol. 2010;16(September (36)):4515–4518. - PMC - PubMed