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Review
. 2016 Mar;116(3):183-7.
doi: 10.1016/j.anai.2015.10.026.

Immunoglobulin E, what is it good for?

Brian T Kelly  1 , Mitchell H Grayson  2
Affiliations
Review

Immunoglobulin E, what is it good for?

Brian T Kelly et al. Ann Allergy Asthma Immunol. 2016 Mar.
No abstract available

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Figures

Figure 1
Figure 1. The many roles of IgE
IgE can bind to either FcεRI (the high-affinity receptor for IgE, composed of either an α, β, and 2 γ chains or simply an α and 2 γ chains) or CD23 (the low-affinity receptor, here shown as a trimer, although it also occurs as a monomer), with the resulting functions for each receptor shown. Shown with the “crown”, IgE is most known for its role in allergic disease. However, as discussed in the text, via FcεRI, IgE has been shown to play a role in antiviral immune responses to respiratory viruses, protection from toxin exposure, as a sensor for small quantities, and as part of the immune response against parasites. Through CD23, IgE has been demonstrated to operate as a sensor for small quantities, play a role in the immune response against parasites, and regulate IgE synthesis by B cells.
See this image and copyright information in PMC

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