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. 2016 Jul 1;21(4):e456-64.
doi: 10.4317/medoral.21105.

Association between susceptible genotypes to periodontitis and clinical outcomes of periodontal regenerative therapy: A systematic review

G-S Chatzopoulos  1 , V-P Koidou
Affiliations

Association between susceptible genotypes to periodontitis and clinical outcomes of periodontal regenerative therapy: A systematic review

G-S Chatzopoulos et al. Med Oral Patol Oral Cir Bucal. .

Abstract

Background: The aim of this review is to systematically investigate the effect of a susceptible genotype to periodontitis with the clinical outcomes of periodontal regeneration.

Material and methods: Based on a focused question, an electronic search identified 155 unique citations. Three journals (Journal of Periodontology, Journal of Clinical Periodontology and Journal of Periodontal Research), references of relevant studies and review articles were hand-searched. Two independent reviewers implementing eligibility inclusion criteria selected the studies.

Results: Of the 155, four studies fulfilled the inclusion criteria. All studies were published between 2000 and 2004 and the samples' size was 40 to 86 patients. Polymorphisms of Interleukin-1 (IL-1) gene were included in all. Three out of four studies failed to identify an association between susceptible genotypes to periodontitis and clinical outcomes of periodontal regeneration, while one found an association. The heterogeneity and small number of studies included prevented the conduct of a meta-analysis. No studies were identified evaluating the effect of other genotypes and as a result only IL-1 genotype studies were included.

Conclusions: Within the limits of the present review, no direct conclusion for the effect of a susceptible IL-1 genotype status to the clinical outcome after periodontal regeneration could be drawn. The need of more qualitative studies to explore a possible association emerges.

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Conflict of interest statement

Conflict of interest statement: The authors have declared that no conflict of interest exist.

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References

    1. Wang HL, Greenwell H, Fiorellini J, Giannobile W, Offenbacher S, Salkin L. Research, Science and Therapy Committee. Periodontal regeneration. J Periodontol. 2005;76:1601–22. - PubMed
    1. Villar CC, Cochran DL. Regeneration of periodontal tissues: guided tissue regeneration. Dent Clin North Am. 2010;54:73–92. - PubMed
    1. Reynolds MA, Aichelmann-Reidy ME, Branch-Mays GL, Gunsolley JC. The efficacy of bone replacement grafts in the treatment of periodontal osseous defects. A systematic review. Ann Periodontol. 2003;8:227–65. - PubMed
    1. Trombelli L. Which reconstructive procedures are effective for treating the periodontal intraosseous defect? Periodontol 2000. 2005;37:88–105. - PubMed
    1. Nyman S, Lindhe J, Karring T, Rylander H. New attachment following surgical treatment of human periodontal disease. J Clin Periodontol. 1982;9:290–6. - PubMed

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