Modulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis by Helicobacter pylori in immune pathogenesis of gastric mucosal damage
- PMID: 26947589
- DOI: 10.1016/j.jmii.2016.01.002
Modulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis by Helicobacter pylori in immune pathogenesis of gastric mucosal damage
Abstract
Helicobacter pylori infection is associated with chronic gastritis, peptic ulcer, gastric carcinoma, and gastric mucosa-associated lymphoid tissue lymphomas. Apoptosis induced by microbial infections is implicated in the pathogenesis of H. pylori infection. Enhanced gastric epithelial cell apoptosis during H. pylori infection was suggested to play an important role in the pathogenesis of chronic gastritis and gastric pathology. In addition to directly triggering apoptosis, H. pylori induces sensitivity to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in gastric epithelial cells. Human gastric epithelial cells sensitized to H. pylori confer susceptibility to TRAIL-mediated apoptosis via modulation of death-receptor signaling. The induction of TRAIL sensitivity by H. pylori is dependent upon the activation of caspase-8 and its downstream pathway. H. pylori induces caspase-8 activation via enhanced assembly of the TRAIL death-inducing signaling complex through downregulation of cellular FLICE-inhibitory protein. Moreover, H. pylori infection induces infiltration of T lymphocytes and triggers inflammation to augment apoptosis. In H. pylori infection, significant increases in CCR6+ CD3+ T cell infiltration in the gastric mucosa was observed, and the CCR6 ligand, CCL20 chemokine, was selectively expressed in inflamed gastric tissues. These mechanisms initiate chemokine-mediated T lymphocyte trafficking into inflamed epithelium and induce mucosal injury during Helicobacter infection. This article will review recent findings on the interactions of H. pylori with host-epithelial signaling pathways and events involved in the initiation of gastric pathology, including gastric inflammation and mucosal damage.
Keywords: FLIP; Helicobacter pylori; TRAIL; apoptosis; chemokine.
Copyright © 2016. Published by Elsevier B.V.
Similar articles
-
Interplay between Helicobacter pylori and immune cells in immune pathogenesis of gastric inflammation and mucosal pathology.Cell Mol Immunol. 2010 Jul;7(4):255-9. doi: 10.1038/cmi.2010.2. Epub 2010 Mar 1. Cell Mol Immunol. 2010. PMID: 20190789 Free PMC article. Review.
-
Helicobacter pylori sensitizes TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human gastric epithelial cells through regulation of FLIP.Cell Death Dis. 2014 Mar 6;5(3):e1109. doi: 10.1038/cddis.2014.81. Cell Death Dis. 2014. PMID: 24603337 Free PMC article.
-
Upregulation of CCL20 and recruitment of CCR6+ gastric infiltrating lymphocytes in Helicobacter pylori gastritis.Infect Immun. 2007 Sep;75(9):4357-63. doi: 10.1128/IAI.01660-06. Epub 2007 Jun 11. Infect Immun. 2007. PMID: 17562763 Free PMC article.
-
Helicobacter pylori enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in human gastric epithelial cells.World J Gastroenterol. 2004 Aug 15;10(16):2334-9. doi: 10.3748/wjg.v10.i16.2334. World J Gastroenterol. 2004. PMID: 15285015 Free PMC article.
-
Apoptosis in gastric epithelium induced by Helicobacter pylori infection: implications in gastric carcinogenesis.Am J Gastroenterol. 2001 Jan;96(1):16-26. doi: 10.1111/j.1572-0241.2001.03447.x. Am J Gastroenterol. 2001. PMID: 11197247 Review.
Cited by
-
Inhibition of Bcl6b promotes gastric cancer by amplifying inflammation in mice.Cell Commun Signal. 2019 Jul 9;17(1):72. doi: 10.1186/s12964-019-0387-6. Cell Commun Signal. 2019. PMID: 31288844 Free PMC article.
-
Apoptosis and its pathways as targets for intracellular pathogens to persist in cells.Parasitol Res. 2023 Dec 19;123(1):60. doi: 10.1007/s00436-023-08031-x. Parasitol Res. 2023. PMID: 38112844 Free PMC article. Review.
-
Dysregulated Expression of Apoptosis-Associated Genes and MicroRNAs and Their Involvement in Gastric Carcinogenesis.J Gastrointest Cancer. 2021 Jun;52(2):625-633. doi: 10.1007/s12029-019-00353-3. J Gastrointest Cancer. 2021. PMID: 32583363
-
Current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: a comprehensive review.Front Cell Dev Biol. 2024 Dec 10;12:1513426. doi: 10.3389/fcell.2024.1513426. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 39720008 Free PMC article. Review.
-
LPS-induced CXCR7 expression promotes gastric Cancer proliferation and migration via the TLR4/MD-2 pathway.Diagn Pathol. 2019 Jan 12;14(1):3. doi: 10.1186/s13000-019-0780-x. Diagn Pathol. 2019. PMID: 30636642 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous