Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Mar 3:4:6.
doi: 10.1186/s40364-016-0060-9. eCollection 2016.

SOX11 is a biomarker for cyclin D1-negative mantle cell lymphoma

Roshni Narurkar  1 , Mohammad Alkayem  1 , Delong Liu  1
Affiliations
Review

SOX11 is a biomarker for cyclin D1-negative mantle cell lymphoma

Roshni Narurkar et al. Biomark Res. .

Abstract

Cyclin D1 (CCND1) protein overexpression and/or the t(11;14)(q13;q32) translocation are the pathognomonic hallmarks of mantle cell lymphoma (MCL). However, there have been cases that lacked both t(11;14) and cyclin D1 protein but still had a gene expression profile suggesting a diagnosis of MCL. SOX11 expression was detected in most cyclin D1- negative MCL and can serve as a specific biomarker for the diagnosis of this subset of MCL. Lack of SOX11 expression in MCL was associated with an indolent subset and favorable prognosis.

PubMed Disclaimer

References

    1. Sabattini E, Bacci F, Sagramoso C, Pileri SA. WHO classification of tumours of haematopoietic and lymphoid tissues in 2008: an overview. Pathologica. 2010;102(3):83–7. - PubMed
    1. Tiemann M, Schrader C, Klapper W, Dreyling MH, Campo E, Norton A, et al. Histopathology, cell proliferation indices and clinical outcome in 304 patients with mantle cell lymphoma (MCL): a clinicopathological study from the European MCL Network. Br J Haematol. 2005;131(1):29–38. doi: 10.1111/j.1365-2141.2005.05716.x. - DOI - PubMed
    1. Hamborg KH, Bentzen HH, Grubach L, Hokland P, Nyvold CG. A highly sensitive and specific qPCR assay for quantification of the biomarker SOX11 in mantle cell lymphoma. Eur J Haematol. 2012;89(5):385–94. doi: 10.1111/j.1600-0609.2012.01837.x. - DOI - PubMed
    1. Mozos A, Royo C, Hartmann E, De Jong D, Baro C, Valera A, et al. SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype. Haematologica. 2009;94(11):1555–62. doi: 10.3324/haematol.2009.010264. - DOI - PMC - PubMed
    1. Furtado M, Rule S. Indolent mantle cell lymphoma. Haematologica. 2011;96(8):1086–8. doi: 10.3324/haematol.2011.047357. - DOI - PMC - PubMed

LinkOut - more resources