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. 2016 Mar 18;18(6):1234-7.
doi: 10.1021/acs.orglett.5b03690. Epub 2016 Mar 7.

Direct Oxidation of Aliphatic C-H Bonds in Amino-Containing Molecules under Transition-Metal-Free Conditions

Xin Li, Xing Che, Gui-Hua Chen, Jun Zhang, Jia-Lei Yan, Yun-Fei Zhang, Li-Sheng Zhang, Chao-Ping Hsu  1 , Yi Qin Gao, Zhang-Jie Shi  2
Affiliations

Direct Oxidation of Aliphatic C-H Bonds in Amino-Containing Molecules under Transition-Metal-Free Conditions

Xin Li et al. Org Lett. .

Abstract

By employing a simple, inexpensive, and transition-metal-free oxidation system, secondary C-H bonds in a series of phthaloyl protected primary amines and amino acid derivatives were oxidized to carbonyls with good regioselectivities. This method could also be applied to oxidize tertiary C-H bonds and modify synthetic dipeptides.

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