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. 2016 Oct;30(19):2149-53.
doi: 10.1080/14786419.2016.1146886. Epub 2016 Mar 7.

Noralashinol A, a new norlignan from stem barks of Syringa pinnatifolia

Guozhu Su  1   2 , Ruifeng Bai  1   2 , Xuelong Yu  1   2 , Yuan Cao  1   2 , Xu Yin  1   2 , Pengfei Tu  1 , Xingyun Chai  1
Affiliations

Noralashinol A, a new norlignan from stem barks of Syringa pinnatifolia

Guozhu Su et al. Nat Prod Res. 2016 Oct.

Abstract

One new norlignan, namely noralashinol A (1), one known analogue (2), together with seven known lignans (3-9) were isolated from the stem barks of Syringa pinnatifolia. Their structures were elucidated extensively by spectroscopic methods, including mass spectrometry and 1D and 2D NMR spectroscopies. Compound 8 significantly inhibited NO production in LPS-induced BV-2 murine microglia cells with its IC50 value of 20.7 μM, compared to a positive control quercetin with its IC50 value of 15.3 μM.

Keywords: Syringa pinnatifolia; anti-inflammatory activity; noralashinol A.

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