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. 2016 Jul 1;214(1):161-5.
doi: 10.1093/infdis/jiw095. Epub 2016 Mar 6.

Myocardial Infarction-Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease

Amanda Farage Frade  1 , Laurie Laugier  2 , Ludmila Rodrigues Pinto Ferreira  3 , Monique Andrade Baron  4 , Luiz Alberto Benvenuti  5 , Priscila Camillo Teixeira  4 , Isabela Cunha Navarro  4 , Sandrine Cabantous  2 , Frederico Moraes Ferreira  3 , Darlan da Silva Cândido  4 , Fabio Antônio Gaiotto  5 , Fernando Bacal  6 , Pablo Pomerantzeff  6 , Ronaldo Honorato Barros Santos  5 , Jorge Kalil  7 , Edecio Cunha-Neto  4 , Christophe Chevillard  2
Affiliations

Myocardial Infarction-Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease

Amanda Farage Frade et al. J Infect Dis. .

Abstract

Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction-associated transcript (MIAT) has been associated with myocardial infarction. Chagas disease causes a severe inflammatory dilated chronic cardiomyopathy (CCC). We investigated the role of MIAT in CCC. A whole-transcriptome analysis of heart biopsy specimens and formalin-fixed, paraffin-embedded samples revealed that MIAT was overexpressed in patients with CCC, compared with subjects with noninflammatory dilated cardiomyopathy and controls. These results were confirmed in a mouse model. Results suggest that MIAT is a specific biomarker of CCC.

Keywords: Chagas disease; MIAT; biomarker; cardiomyopathy; dilated; lncRNA.

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