Post-translational modifications in Pseudomonas aeruginosa revolutionized by proteomic analysis

Abstract

Pseudomonas aeruginosa is an opportunistic pathogen that causes severe infections in vulnerable individuals. It is known that post-translational modifications (PTMs) play a key role in bacterial physiology. Their characterization is still challenging and the recent advances in proteomics allow large-scale and high-throughput analyses of PTMs. Here, we provide an overview of proteomic data about the modified proteins in P. aeruginosa. We emphasize the significant contribution of proteomics in knowledge enhancement of PTMs (phosphorylation, N-acetylation and glycosylation) and we discuss their importance in P. aeruginosa physiology.

Keywords: Acetylation; Glycosylation; Phosphorylation; Post-translational modifications; Proteomics; Pseudomonas aeruginosa.