Effects of cilofungin (LY121019) on carbohydrate and sterol composition of Candida albicans
- PMID: 2695329
- DOI: 10.1007/BF01975172
Effects of cilofungin (LY121019) on carbohydrate and sterol composition of Candida albicans
Abstract
Cilofungin (LY 121019) is a novel analogue of echinocandin B with potent activity against Candida albicans. The effects of cilofungin on the sterol and cell wall carbohydrate composition of Candida albicans were investigated. Exposure of Candida albicans to cilofungin resulted in a 55-60% decrease in ergosterol and a 4-13% decrease in lanosterol content relative to controls. Carbohydrate analysis revealed a 72-79% decrease in glucan content and no significant decrease in mannan or chitin content relative to controls. These studies suggest that cilofungin specifically inhibits glucan synthesis in Candida albicans and thus may be less toxic to mammalian cells. The effects of cilofungin on sterol composition may be non-specific and will require additional investigation.
Similar articles
-
Effects of fluconazole on the sterol and carbohydrate composition of four species of Candida.Eur J Clin Microbiol Infect Dis. 1992 Feb;11(2):152-6. doi: 10.1007/BF01967067. Eur J Clin Microbiol Infect Dis. 1992. PMID: 1396728
-
Effects of terconazole and other azole antifungal agents on the sterol and carbohydrate composition of Candida albicans.Diagn Microbiol Infect Dis. 1990 Jan-Feb;13(1):31-5. doi: 10.1016/0732-8893(90)90050-6. Diagn Microbiol Infect Dis. 1990. PMID: 2184984
-
The lipopeptide antimycotic, cilofungin modulates the incorporation of glucan-associated proteins into the cell wall of Candida albicans.J Antimicrob Chemother. 1994 Jun;33(6):1137-46. doi: 10.1093/jac/33.6.1137. J Antimicrob Chemother. 1994. PMID: 7928807
-
Molecular bases of adhesion of Candida albicans.J Med Vet Mycol. 1997 Mar-Apr;35(2):87-99. doi: 10.1080/02681219780000971. J Med Vet Mycol. 1997. PMID: 9147268 Review.
-
Linkages between macromolecules in Candida albicans cell wall.Arch Med Res. 1993 Autumn;24(3):305-10. Arch Med Res. 1993. PMID: 8298282 Review.
Cited by
-
Micafungin in the treatment of invasive candidiasis and invasive aspergillosis.Infect Drug Resist. 2008;1:63-77. Epub 2009 Jan 12. Infect Drug Resist. 2008. PMID: 21694882 Free PMC article.
-
Effects of fluconazole on the sterol and carbohydrate composition of four species of Candida.Eur J Clin Microbiol Infect Dis. 1992 Feb;11(2):152-6. doi: 10.1007/BF01967067. Eur J Clin Microbiol Infect Dis. 1992. PMID: 1396728
-
Aerosol and parenteral pneumocandins are effective in a rat model of pulmonary aspergillosis.Antimicrob Agents Chemother. 1995 Aug;39(8):1784-9. doi: 10.1128/AAC.39.8.1784. Antimicrob Agents Chemother. 1995. PMID: 7486919 Free PMC article.
-
Comparative efficacies of cilofungin (Ly121019) and amphotericin B against disseminated Candida albicans infection in normal and granulocytopenic mice.Antimicrob Agents Chemother. 1993 Apr;37(4):729-36. doi: 10.1128/AAC.37.4.729. Antimicrob Agents Chemother. 1993. PMID: 8494367 Free PMC article.
-
Increases in SLT2 expression and chitin content are associated with incomplete killing of Candida glabrata by caspofungin.Antimicrob Agents Chemother. 2008 Mar;52(3):1144-6. doi: 10.1128/AAC.01542-07. Epub 2007 Dec 17. Antimicrob Agents Chemother. 2008. PMID: 18086838 Free PMC article.